Exploratory Clinical Trial to Evaluate the Efficacy of a Topical Traditional Chinese Herbal Medicine in Psoriasis Vulgaris

Table 3

Summary of the secondary efficacy criteria (ITT-LOCF). ⁽¹⁾CMH test using row mean score difference statistic and ridit transformation.

		Dimeticone/placebo		Shi Du Ruan Gao		value^(1)
		Raw data	Change from baseline	Raw data	Change from baseline	Change from baseline
TSS		50	50	50	50	<0.001
	Mean ± SD	5.1 ± 2.1	−1.3 ± 1.4	2.7 ± 2.2	−3.8 ± 1.9
	Median	5.0	−1.0	2.0	−4.5
	Min~Max	0~10	−5~1	0~8	−7~0
	1~	4~6	−2~0	1~4	−5~−3
Erythema		50	50	50	50	<0.001
	Mean ± SD	1.9 ± 0.8	−0.3 ± 0.7	1.2 ± 0.7	−1.2 ± 0.7
	Median	2.0	0.0	1.0	−1.0
	Min~Max	0~4	−2~1	0~3	−2~1
	1~	1.0~2.0	−1.0~0.0	1.0~2.0	−2.0~1.0
Plaque elevation		50	50	50	50	<0.001
	Mean ± SD	1.7 ± 0.8	−0.4 ± 0.6	0.8 ± 0.9	−1.5 ± 0.9
	Median	2.0	0.0	0.5	−2.0
	Min~Max	0~3	−2~1	0~3	−3~0
	1~	1.0~2.0	−1.0~0.0	0.0~1.0	−2.0~1.0
Scaling		50	50	50	50	<0.001
	Mean ± SD	1.5 ± 0.9	−0.6 ± 0.8	0.8 ± 0.9	−1.1 ± 0.8
	Median	1.0	0.0	1.0	−1.0
	Min~Max	0~4	−2~1	0~3	−3~0
	1~	1.0~2.0	−1.0~0.0	0.0~1.0	−2.0~1.0