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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 725023, 12 pages
http://dx.doi.org/10.1155/2015/725023
Research Article

Anticancer Activity of Saponins from Allium chinense against the B16 Melanoma and 4T1 Breast Carcinoma Cell

Hunan Provincial Key Laboratory of Microbial Molecular Biology-State Key Laboratory Breeding Base of Microbial Molecular Biology, College of Life Science, Hunan Normal University, Changsha 410081, China

Received 28 January 2015; Accepted 20 March 2015

Academic Editor: Avni Sali

Copyright © 2015 Zhihui Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Mahmoodi, M. R. Islami, G. R. A. Karam et al., “Study of the effects of raw garlic consumption on the level of lipids and other blood biochemical factors in hyperlipidemic individuals,” Pakistan Journal of Pharmaceutical Sciences, vol. 19, no. 4, pp. 295–298, 2006. View at Google Scholar · View at Scopus
  2. A. Bordia, S. K. Verma, and K. C. Srivastava, “Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease,” Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 56, no. 5, pp. 379–384, 1997. View at Publisher · View at Google Scholar · View at Scopus
  3. G. A. Benavides, G. L. Squadrito, R. W. Mills et al., “Hydrogen sulfide mediates the vasoactivity of garlic,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 46, pp. 17977–17982, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. S. K. Banerjee and S. K. Maulik, “Effect of garlic on cardiovascular disorders: a review,” Nutrition Journal, vol. 1, article 4, 2002. View at Publisher · View at Google Scholar
  5. Q. Peng, A. R. Buzzard, and B. H. Lau, “Neuroprotective effect of garlic compounds in amyloid-beta peptide-induced anticancer activity in vitro,” Medical Science Monitor, vol. 8, no. 8, pp. 328–337, 2002. View at Google Scholar
  6. N. B. Chauhan, “Effect of aged garlic extract on APP processing and tau phosphorylation in Alzheimer's transgenic model Tg2576,” Journal of Ethnopharmacology, vol. 108, no. 3, pp. 385–394, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Fukao, H. Yoshida, Y. I. Tazawa, and T. Hada, “Antithrombotic effects of odorless garlic powder both in vitro and in vivo,” Bioscience, Biotechnology and Biochemistry, vol. 71, no. 1, pp. 84–90, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Higuchi, Y. Shimizu, T. TYasumura, and A. Watanabe, “Preventive effect of liver carcinogenesis by Juzen-Taiho-To in the patients with liver cirrhosis,” Liver, Gallbladder and Pancreas, vol. 44, pp. 341–346, 2002. View at Google Scholar
  9. K. Sasaki, H. Takasaka, and K. Hirata, “Suppressive effect of Kampo Japanese herbal medicine on hepatic tumor metastasis,” Japanese Journal of Cancer Clinics, vol. 48, pp. 171–176, 2002. View at Google Scholar
  10. S. Ohkawa and K. Tarao, “The prevention of hepatocellular carcinoma development by the improvement of serum transaminase in patients with Hepatitis C,” Clinical Gastroenterology, vol. 21, pp. 318–323, 2006. View at Google Scholar
  11. M. Pandey, P. Kaur, S. Shukla, A. Abbas, P. Fu, and S. Gupta, “Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and anticancer activity in human prostate cancer cells in vitro and in vivo study,” Molecular Carcinogenesis, vol. 10, pp. 1–11, 2011. View at Google Scholar
  12. M. E. S. Kassem, S. Shoela, M. M. Marzouk, and A. A. Sleem, “A sulphated flavone glycoside from Livistona australis and its antioxidant and cytotoxic activity,” Natural Product Research, vol. 26, no. 15, pp. 1381–1387, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. O. Samoylenko, S. Zaletok, O. Orlovsky, and S. Gogol, “Additive antitumor effect of plant polyphenols and synthetic inhibitors of polyamines biosynthesis,” Experimental Oncology, vol. 33, no. 3, pp. 186–189, 2011. View at Google Scholar · View at Scopus
  14. J. Wang, X. Chen, L. Hou, L. Li, H. Lu, and W. Liu, “Effects of tea polyphenols on the expression of NF-κB, COX-2 and survivin in Lewis lung carcinoma xenografts in C57BL/6 mice,” Zhongguo Fei Ai Za Zhi, vol. 15, no. 5, pp. 271–276, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. D. Kitagawa, Y. Nako, Y. Honda et al., “A case of primary breast cancer responding to pre-operative chemotherapy with the combination of paclitaxel and carboplatin for ovarian cancer,” Gan To Kagaku Ryoho, vol. 39, no. 6, pp. 1013–1016, 2012. View at Google Scholar · View at Scopus
  16. R. K. Hanna, C. Zhou, K. M. Malloy et al., “Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway,” Gynecologic Oncology, vol. 125, no. 2, pp. 458–469, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Bandyopadhyay and R. A. Gjerset, “Protein kinase CK2 Is a central regulator of topoisomerase I hyperphosphorylation and camptothecin sensitivity in cancer cell lines,” Biochemistry, vol. 50, no. 5, pp. 704–714, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Mollica, A. Stefanucci, F. Feliciani, I. Cacciatore, C. Cornacchia, and F. Pinnen, “Delivery methods of camptothecin and its hydrosoluble analogue irinotecan for treatment of colorectal cancer,” Current Drug Delivery, vol. 9, no. 2, pp. 122–131, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. P. Fresco, F. Borges, C. Diniz, and M. P. M. Marques, “New insights on the anticancer properties of dietary polyphenols,” Medicinal Research Reviews, vol. 26, no. 6, pp. 747–766, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Susanto, N. Fakhrudin, Y. B. Murti, and W. Siswomiharjo, “Saponins from Plumeria acuminata Ait induce cell growth inhibition and apoptosis of oral squamous carcinoma cells,” The Chinese Journal of Dental Research, vol. 13, no. 2, pp. 153–156, 2010. View at Google Scholar · View at Scopus
  21. M. Arabski, A. Węgierek-Ciuk, G. Czerwonka, A. Lankoff, and W. Kaca, “Effects of saponins against clinical E. coli strains and eukaryotic cell line,” Journal of Biomedicine and Biotechnology, vol. 2012, Article ID 286216, 6 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. K. Pérez-Labrada, I. Brouard, S. Estévez et al., “New insights into the structure-cytotoxicity relationship of spirostan saponins and related glycosides,” Bioorganic & Medicinal Chemistry, vol. 20, no. 8, pp. 2690–2700, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. S. A. Nag, J.-J. Qin, W. Wang, M.-H. Wang, H. Wang, and R. Zhang, “Ginsenosides as anticancer agents: in vitro and in vivo activities, structure-activity relationships, and molecular mechanisms of action,” Frontiers in Pharmacology, vol. 3, article 25, 18 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. W. Zhang, G. Chen, and C.-Q. Deng, “Effects and mechanisms of total Panax notoginseng saponins on proliferation of vascular smooth muscle cells with plasma pharmacology method,” Journal of Pharmacy and Pharmacology, vol. 64, no. 1, pp. 139–145, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. Y. C. Si, J. P. Zhang, C. E. Xie, L. J. Zhang, and X. N. Jiang, “Effects of Panax notoginseng saponins on proliferation and differentiation of rat hippocampal neural stem cells,” American Journal of Chinese Medicine, vol. 39, no. 5, pp. 999–1013, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. L. Sun, S. Lin, R. Zhao, B. Yu, S. Yuan, and L. Zhang, “The saponin monomer of dwarf lilyturf tuber, DT-13, reduces human breast cancer cell adhesion and migration during hypoxia via regulation of tissue factor,” Biological and Pharmaceutical Bulletin, vol. 33, no. 7, pp. 1192–1198, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. M.-C. Lu, T.-Y. Lai, J.-M. Hwang et al., “Proliferation- and migration-enhancing effects of ginseng and ginsenoside Rg1 through IGF-I- and FGF-2-signaling pathways on RSC96 Schwann cells,” Cell Biochemistry and Function, vol. 27, no. 4, pp. 186–192, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Chen, H. Peng, X. Ou-Yang, and X. He, “Research on the antitumor effect of ginsenoside Rg3 in B16 melanoma cells,” Melanoma Research, vol. 18, no. 5, pp. 322–329, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. X.-H. Han, Y.-Y. Ye, B.-F. Guo, and S. Liu, “Effects of platycodin D in combination with different active ingredients of Chinese herbs on proliferation and invasion of 4T1 and MDA-MB-231 breast cancer cell lines,” Journal of Chinese Integrative Medicine, vol. 10, no. 1, pp. 67–75, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. J. A. Pino, V. Fuentes, and M. T. Correa, “Volatile constituents of Chinese chive (Allium tuberosum Rottl. ex Sprengel) and Rakkyo (Allium chinense G. Don),” Journal of Agricultural and Food Chemistry, vol. 49, no. 3, pp. 1328–1330, 2001. View at Publisher · View at Google Scholar · View at Scopus
  31. V. Lanzotti, “Bioactive saponins from Allium and Aster Plants,” Phytochemistry Reviews, vol. 4, no. 2-3, pp. 95–110, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. H. Luo, J. Huang, W.-G. Liao, Q.-Y. Huang, and Y.-Q. Gao, “The antioxidant effects of garlic saponins protect PC12 cells from hypoxia-induced damage,” British Journal of Nutrition, vol. 105, no. 8, pp. 1164–1172, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. H. Zhou, X. Yang, N. L. Wang, Y. O. Zhang, and G. P. Cai, “Macrostemonoside a promotes visfatin expression in 3T3-L1 cells,” Biological and Pharmaceutical Bulletin, vol. 30, no. 2, pp. 279–283, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. H.-F. Chen, G.-H. Wang, Q. Luo, N.-L. Wang, and X.-S. Yao, “Two new steroidal saponins from Allium macrostemon bunge and their cytotoxity on different cancer cell lines,” Molecules, vol. 14, no. 6, pp. 2246–2253, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. G.-J. Du, C.-Z. Wang, Z.-Y. Zhang et al., “Caspase-mediated pro-apoptotic interaction of panaxadiol and irinotecan in human colorectal cancer cells,” Journal of Pharmacy and Pharmacology, vol. 64, no. 5, pp. 727–734, 2012. View at Publisher · View at Google Scholar · View at Scopus
  36. T. Inoue, Y. Mimaki, Y. Sashida, A. Nishino, Y. Satomi, and H. Nishino, “Steroidal glycosides from Allium macleanii and A. senescens, and their inhibitory activity on tumour promoter-induced phospholipid metabolism of HeLa cells,” Phytochemistry, vol. 40, no. 2, pp. 521–525, 1995. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Kampa, A. Hatzoglou, G. Notas et al., “Wine antioxidant polyphenols inhibit the proliferation of human prostate cancer cell lines,” Nutrition and Cancer, vol. 37, no. 2, pp. 223–233, 2000. View at Google Scholar · View at Scopus
  38. J. H. Weisburg, D. B. Weissman, T. Sedaghat, and H. Babich, “In vitro cytotoxicity of epigallocatechin gallate and tea extracts to cancerous and normal cells from the human oral cavity,” Basic and Clinical Pharmacology and Toxicology, vol. 95, no. 4, pp. 191–200, 2004. View at Google Scholar · View at Scopus
  39. M. Oświecimska, J. Sendra, and Z. Janeczko, “Antimitotic activity of saponin fractions and extracts from Rx. primulae, Rx. saponariae and Sem. Hippocastani,” Polish Journal of Pharmacology and Pharmacy, vol. 27, no. 3, pp. 349–354, 1975. View at Google Scholar · View at Scopus
  40. Y. Mimaki, O. Nakamura, Y. Sashida, T. Nikaido, and T. Ohmoto, “Steroidal saponins from the bulbs of Triteleia lactea and their inhibitory activity on cyclic AMP phosphodiesterase,” Phytochemistry, vol. 38, no. 5, pp. 1279–1286, 1995. View at Publisher · View at Google Scholar · View at Scopus
  41. M. Kuroda, Y. Mimaki, A. Kameyama, Y. Sashida, and T. Nikaido, “Steroidal saponins from Allium chinense and their inhibitory activities on cyclic AMP phosphodiesterase and Na+ K+ ATPase,” Phytochemistry, vol. 40, no. 4, pp. 1071–1076, 1995. View at Publisher · View at Google Scholar · View at Scopus
  42. J. P. Peng, H. Chen, Y. Q. Qiao et al., “Two new steroidal saponins from Allium sativum and their inhibitory effects on blood coagulability,” Yao Xue Xue Bao, vol. 31, no. 8, pp. 607–612, 1996. View at Google Scholar · View at Scopus
  43. N. Sata, S. Matsunaga, N. Fusetani, H. Nishikawa, S. Takamura, and T. Saito, “New antifungal and cytotoxic steroidal saponins from the bulbs of an elephant garlic mutant,” Bioscience, Biotechnology and Biochemistry, vol. 62, no. 10, pp. 1904–1911, 1998. View at Publisher · View at Google Scholar · View at Scopus
  44. E. Neeley, G. Fritch, A. Fuller, J. Wolfe, J. Wright, and W. Flurkey, “Variations in IC50 values with purity of mushroom tyrosinase,” International Journal of Molecular Sciences, vol. 10, no. 9, pp. 3811–3823, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. C. A. Burkhart, F. Watt, J. Murray et al., “Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapyin mouse models of neuroblastoma,” Cancer Research, vol. 69, no. 16, pp. 6573–6580, 2009. View at Publisher · View at Google Scholar · View at Scopus
  46. M. H. Kershaw, J. T. Jackson, N. M. Haynes et al., “Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer,” Journal of Immunology, vol. 173, no. 3, pp. 2143–2150, 2004. View at Publisher · View at Google Scholar · View at Scopus
  47. Y.-C. Si, J.-P. Zhang, C.-E. Xie, L.-J. Zhang, and X.-N. Jiang, “Effects of Panax notoginseng saponins on proliferation and differentiation of rat hippocampal neural stem cells,” The American Journal of Chinese Medicine, vol. 39, no. 5, pp. 999–1013, 2011. View at Publisher · View at Google Scholar · View at Scopus
  48. Y. Zhang, X. Xu, and P. He, “Tubeimoside-1 inhibits proliferation and induces apoptosis by increasing the Bax to Bcl-2 ratio and decreasing COX-2 expression in lung cancer A549 cells,” Molecular Medicine Reports, vol. 4, no. 1, pp. 25–29, 2011. View at Publisher · View at Google Scholar · View at Scopus
  49. M. C. Lu, T. Y. Lai, J. M. Hwang et al., “Proliferation- and migration-enhancing effects of ginseng and ginsenoside Rg1 through IGF-I- and FGF-2-signaling pathways on RSC96 Schwann cells,” Cell Biochemistry and Function, vol. 27, no. 4, pp. 186–192, 2009. View at Publisher · View at Google Scholar · View at Scopus
  50. A.-W. Shi, X.-B. Wang, F.-X. Lu, M.-M. Zhu, X.-Q. Kong, and K.-J. Cao, “Ginsenoside Rg1 promotes endothelial progenitor cell migration and proliferation,” Acta Pharmacologica Sinica, vol. 30, no. 3, pp. 299–306, 2009. View at Publisher · View at Google Scholar · View at Scopus
  51. H. Luo, J. Huang, W.-G. Liao, Q.-Y. Huang, and Y.-Q. Gao, “The antioxidant effects of garlic saponins protect PC12 cells from hypoxia-induced damage,” British Journal of Nutrition, vol. 105, no. 8, pp. 1164–1172, 2011. View at Publisher · View at Google Scholar · View at Scopus
  52. H. Zhou, X. Yang, N.-L. Wang, Y.-O. Zhang, and G.-P. Cai, “Macrostemonoside a promotes visfatin expression in 3T3-L1 cells,” Biological and Pharmaceutical Bulletin, vol. 30, no. 2, pp. 279–283, 2007. View at Publisher · View at Google Scholar · View at Scopus
  53. M. X. Li, Y. R. Wang, J. M. Cao, G. Z. Tian, and L. H. Zhao, “To explore the double-labeling method of monitoring the GHRP regulatory function on [Ca2+] and NO on real time in card iomyocytes under LSCM,” Journal of Medical Research, vol. 36, no. 8, pp. 136–143, 2007. View at Google Scholar
  54. Y. Huang, M. Yang, H. Yang, and Z. Zeng, “Upregulation of the GRIM-19 gene suppresses invasion and metastasis of human gastric cancer SGC-7901 cell line,” Experimental Cell Research, vol. 316, no. 13, pp. 2061–2070, 2010. View at Publisher · View at Google Scholar · View at Scopus
  55. P. Hebestreit and M. F. Melzig, “Cytotoxic activity of the seeds from Agrostemma githago var. githago,” Planta Medica, vol. 69, no. 10, pp. 921–925, 2003. View at Publisher · View at Google Scholar · View at Scopus
  56. X. Kang, J. Chen, Q. Qin et al., “Isatis tinctoria L. combined with co-stimulatory molecules blockade prolongs survival of cardiac allografts in alloantigen-primed mice,” Transplant Immunology, vol. 23, no. 1-2, pp. 34–39, 2010. View at Publisher · View at Google Scholar · View at Scopus
  57. K. Dabbagh and D. B. Lewis, “Toll-like receptors and T-helper-1/T-helper-2 responses,” Current Opinion in Infectious Diseases, vol. 16, no. 3, pp. 199–204, 2003. View at Publisher · View at Google Scholar · View at Scopus