Herb-Drug Pharmacokinetic Interaction of a Traditional Chinese Medicine Jia-Wei-Xiao-Yao-San with 5-Fluorouracil in the Blood and Brain of Rat Using Microdialysis

Figure 4

HPLC chromatograms of (a) blank brain dialysate; (b) standard 5-FU (5 μg/mL) spiked with blank brain dialysate; and (c) brain sample containing 5-FU (0.9 μg/mL) collected at 15 min after 5-FU (100 mg/kg, i.v.) administration alone. Peak 1: 5-FU and retention time of 5-FU was 6.1 min.

(a)

(b)

(c)