Herb-Drug Pharmacokinetic Interaction of a Traditional Chinese Medicine Jia-Wei-Xiao-Yao-San with 5-Fluorouracil in the Blood and Brain of Rat Using Microdialysis

Table 1

Interday accuracy and precision for analysis of 5-FU in blood and brain microdialysate.

Nominal conc. (g/mL)	Observed conc. (g/mL)	Precision (%)	Accuracy (%)
Blood
0.5	0.54 ± 0.04	7.74	7.06
1	1.03 ± 0.06	6.22	2.92
5	5.13 ± 0.13	2.46	2.61
10	9.75 ± 0.16	1.62	−2.49
50	50.07 ± 0.38	0.77	0.15
100	99.98 ± 0.18	0.18	−0.02
Brain
0.1	0.10 ± 0.01	11.24	−3.52
0.25	0.23 ± 0.01	2.17	−6.85
0.5	0.49 ± 0.03	5.47	−1.52
1	1.03 ± 0.05	5.08	2.65
5	5.01 ± 0.11	2.22	0.15
10	9.99 ± 0.05	0.51	−0.06

Data were expressed as means ± S.D. ( = 6).