Herb-Drug Pharmacokinetic Interaction of a Traditional Chinese Medicine Jia-Wei-Xiao-Yao-San with 5-Fluorouracil in the Blood and Brain of Rat Using Microdialysis

Table 2

Intraday accuracy and precision for analysis of 5-FU in blood and brain microdialysate.

Nominal conc. (g/mL)	Observed conc. (g/mL)	Precision (%)	Accuracy (%)
Blood
0.5	0.55 ± 0.09	16.72	9.76
1	1.05 ± 0.10	9.29	5.45
5	5.05 ± 0.31	6.19	1.05
10	10.16 ± 0.38	3.75	1.56
50	49.42 ± 0.84	1.70	−1.16
100	100.27 ± 0.34	0.34	0.27
Brain
0.1	0.10 ± 0.01	11.45	4.94
0.25	0.24 ± 0.01	3.98	−3.53
0.5	0.51 ± 0.02	4.55	1.44
1	1.06 ± 0.01	1.09	6.26
5	4.88 ± 0.06	1.21	−2.30
10	10.05 ± 0.03	0.27	0.49

Data were expressed as means ± S.D. ( = 6).