Antihypertensive Effect of Radix Paeoniae Alba in Spontaneously Hypertensive Rats and Excessive Alcohol Intake and High Fat Diet Induced Hypertensive Rats
Table 2
Effect of Radix Paeoniae Alba extract on the serum lipid profile and liver functions parameters.
Group
Parameter
TC (mmol/L)
TG (mmol/L)
HDL-C (mmol/L)
LDL-C (mmol/L)
HDL-C/TC ratio
AI
AST (U/L)
ALT (U/L)
SD normal ( = 7)
2.11 ± 0.31
0.53 ± 0.12
0.71 ± 0.09
0.87 ± 0.07
0.34 ± 0.02
1.98 ± 0.18
256.29 ± 42.94
77.43 ± 11.10
ACHFD rats ()
control
3.83 ± 0.4
0.70 ± 0.23
0.46 ± 0.0
1.71 ± 0.2
0.12 ± 0.0
7.79 ± 2.7
323.14 ± 113.79
161.43 ± 90.8
cap
3.68 ± 0.65
0.45 ± 0.1
0.39 ± 0.07
1.71 ± 0.32
0.11 ± 0.03
8.61 ± 2.40
302.71 ± 115.17
180.00 ± 108.25
PH
2.87 ± 0.5
0.80 ± 0.38
0.60 ± 0.1
1.18 ± 0.1
0.21 ± 0.0
3.89 ± 0.8
322.57 ± 86.41
145.57 ± 58.26
PL
3.86 ± 0.54
0.72 ± 0.16
0.45 ± 0.09
1.75 ± 0.28
0.12 ± 0.03
7.96 ± 2.50
211.43 ± 58.6
84.00 ± 32.1
WKY normal ( = 8)
1.81 ± 0.19
0.65 ± 0.23
0.68 ± 0.09
0.36 ± 0.11
0.37 ± 0.04
1.69 ± 0.30
250.88 ± 37.69
69.50 ± 15.52
SHR control ( = 8)
2.23 ± 0.4
0.87 ± 0.2
0.59 ± 0.0
1.33 ± 0.5
0.28 ± 0.0
2.83 ± 0.9
297.50 ± 39.4
109.63 ± 39.9
SHR cap ( = 8)
2.57 ± 0.63
0.76 ± 0.12
0.62 ± 0.13
1.49 ± 0.48
0.24 ± 0.04
3.21 ± 0.74
282.33 ± 80.52
108.14 ± 31.24
SHR PH ( = 8)
2.44 ± 0.46
0.61 ± 0.09
0.69 ± 0.1
1.28 ± 0.21
0.28 ± 0.02
2.54 ± 0.28
285.75 ± 48.38
91.13 ± 13.47
SHR PL ( = 8)
2.72 ± 0.64
0.75 ± 0.23
0.66 ± 0.10
1.48 ± 0.26
0.25 ± 0.03
3.09 ± 0.54
322.63 ± 90.36
88.25 ± 17.55
TC: total cholesterol; TG: triglyceride; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; atherogenic index = (TC-HDL-C)/HDL-C (, versus normal control, , versus model group). ACHFD: Alcohol in conjunction with a high fat diet; cap: captopril; PH: RPA extract high dose group (75 mg/kg); PL: RPA extract low dose group (25 mg/kg).
