Evidence-Based Complementary and Alternative Medicine

Research Article

Effects of Traditional Chinese Medicine on Chemotherapy-Induced Myelosuppression and Febrile Neutropenia in Breast Cancer Patients

Table 1

Clinicopathological data of breast cancer patients.


Variables	Before propensity matching			After propensity matching
Variables	Group 1 ()	Group 2 ()		Group 1 ()	Group 2 ()

Age, yr	50.3 (49.4–51.2)	47.1 (46.1–48.1)	0.000004	49.8 (49.0–50.6)	50.2 (49.3–51.0)	0.504
Chemotherapy			<0.0001			0.250
1	154	35		179	173
2	42	54		63	52
3	172	183		229	260
4	85	87		106	92
TNM stage			0.4594			0.200
I	164	117		215	164
II	219	189		275	333
III and IV	70	53		87	80
Neoadjuvant chemotherapy			0.0029			0.637
Yes	73	88		94	100
No	380	271		483	477
ER			0.000149			0.899
−	146	73		179	177
+	307	286		398	400
PR			0.000244			0.811
−	193	108		237	241
+	260	251		340	336
HER-2			0.003203			0.052
−	340	300		441	468
+	113	59		136	109
Ki67			<0.0001			0.813
−	256	93		304	308
+	197	266		273	269
ALT (U/L)			0.000038			0.008
≤40	382	257		487	446
>40	71	102		90	131
AST (U/L)			0.004			0.224
≤40	394	281		499	483
>40	59	78		78	94

HER-2 positive: testing by immunohistochemical (IHC) assay (3+) or in situ hybridization (ISH) assay (+); HER-2 negative: IHC (−), (1+), and (2+) or ISH (−); ALT: alanine aminotransferase; AST: aspartate transferase. Chemotherapy: 1: the chemotherapy regimens contain AC/EC (Adriamycin or epirubicin, Cyclophosphamide) and CAF/CEF (Adriamycin or epirubicin, Cyclophosphamide, and 5-Fluorouracil). 2: the chemotherapy regimens contain TC (paclitaxel or docetaxel, Cyclophosphamide) and T (paclitaxel or docetaxel). 3: the chemotherapy regimens contain anthracyclines combined with paclitaxel or docetaxel: TAC/TEC (paclitaxel or docetaxel, Cyclophosphamide, and Adriamycin or epirubicin); TA/TE (paclitaxel or docetaxel, Adriamycin or epirubicin). 4: the chemotherapy regimens contain anthracyclines followed by paclitaxel or docetaxel: AC/EC (Adriamycin or epirubicin, Cyclophosphamide); CAF/CEF (Adriamycin or epirubicin, Cyclophosphamide, and 5-Fluorouracil), followed with T or TH (paclitaxel or docetaxel, Herceptin).