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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 736431, 10 pages
Review Article

Pharmacokinetic Interactions of Herbs with Cytochrome P450 and P-Glycoprotein

1College of Pharmacy, Kangwon National University, Chuncheon 200-701, Republic of Korea
2College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, 1666 Youngsan-ro, Muan-gun, Jeonnam 534-729, Republic of Korea

Received 31 July 2014; Revised 20 December 2014; Accepted 20 December 2014

Academic Editor: Angelo A. Izzo

Copyright © 2015 Hyun-Jong Cho and In-Soo Yoon. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The concurrent use of drugs and herbal products is becoming increasingly prevalent over the last decade. Several herbal products have been known to modulate cytochrome P450 (CYP) enzymes and P-glycoprotein (P-gp) which are recognized as representative drug metabolizing enzymes and drug transporter, respectively. Thus, a summary of knowledge on the modulation of CYP and P-gp by commonly used herbs can provide robust fundamentals for optimizing CYP and/or P-gp substrate drug-based therapy. Herein, we review ten popular medicinal and/or dietary herbs as perpetrators of CYP- and P-gp-mediated pharmacokinetic herb-drug interactions. The main focus is placed on previous works on the ability of herbal extracts and their phytochemicals to modulate the expression and function of CYP and P-gp in several in vitro and in vivo animal and human systems.