Antiproliferative and Apoptosis-Inducing Activities of 4-Isopropyl-2,6-bis(1-phenylethyl)phenol Isolated from Butanol Fraction of Cordyceps bassiana

Figure 4

The effect of KTH-13 on the levels of proapoptotic and antiapoptotic proteins. (a, b, and c) C6 glioma cells (5 × 10⁶ cells/mL) were incubated with KTH-13 for the indicated times. After immunoblotting analysis with whole cell lysates, total or cleaved levels of caspases 3, 7, 8, and 9 were identified with specific antibodies. (d) C6 glioma cells (5 × 10⁶ cells/mL) were incubated with KTH-13 for 1 h. The levels of Bax and Bcl-2 from whole cell lysates were analyzed by their specific antibody. All of the data were obtained from one of three independent experiments.

(a)

(b)

(c)

(d)