Vitamin E Analogs as Radiation Response Modifiers

Figure 2

Comparison of tocols and their derivatives with amifostine: (a) comparison of optimum dose, (b) significant protection at highest radiation dose, (c) effective time window for protection and mitigation, and (d) dose-reduction factor for protection and mitigation. Alpha-tocopherol (AT), delta-tocotrienol (DT3), gamma-tocotrienol (GT3), gamma-tocopherol-N,N-dimethylglycine ester (GTDMG), alpha-tocopherol-monoglucoside (TMG), alpha-tocopherol succinate (TS), and amifostine (WR).

(a)

(b)

(c)

(d)