Hypocholesterolemic and Antiatherosclerotic Potential of Basella alba Leaf Extract in Hypercholesterolemia-Induced Rabbits
Table 2
Levels of total cholesterol, LDL, triglycerides, and HDL in serum of rabbits from various groups.
G1
G2
G3
G4
G5
Total cholesterol (mg/dL)
Baseline
39.45 ± 2.95
39.33 ± 3.38
44.37 ± 3.87
41.41 ± 4.58
42.30 ± 4.33
Week 4
42.66 ± 2.67
472.65 ± 4.54
480.83 ± 5.18
506.92 ± 9.57
467.08 ± 8.35
Week 8
46.14 ± 4.06
1104.98 ± 33.32
1112.70 ± 28.33
1002.53 ± 11.51
1038.85 ± 12.35
Week 12
53.57 ± 2.70
1326.91 ± 19.47
456.56 ± 5.23
510.99 ± 8.14
475.12 ± 10.94
LDL level (mg/dL)
Baseline
26.48 ± 0.72
31.19 ± 0.97
25.39 ± 0.43
29.02 ± 1.13
27.03 ± 0.82
Week 4
33.92 ± 0.55
426.15 ± 4.52
440.66 ± 3.39
421.68 ± 3.95
435.94 ± 2.57
Week 8
38.79 ± 0.77
1157.09 ± 13.85
1056.66 ± 15.38
1001.23 ± 12.40
1081.04 ± 4.06
Week 12
45.96 ± 1.01
1259.60 ± 15.43
515.83 ± 14.03
547.39 ± 12.81
539.27 ± 13.05
Triglyceride level (mg/dL)
Baseline
110.13 ± 4.55
116.46 ± 3.68
106.88 ± 6.28
114.39 ± 5.36
107.56 ± 7.58
Week 4
132.83 ± 7.84
340.63 ± 8.74
331.84 ± 4.97
349.42 ± 3.41
329.74 ± 6.95
Week 8
156.38 ± 8.80
654.58 ± 15.16
650.96 ± 18.35
639.52 ± 16.04
661.12 ± 18.81
Week 12
166.03 ± 5.81
869.57 ± 15.38
384.30 ± 14.63
416.14 ± 16.73
398.53 ± 10.66
HDL level (mg/dL)
Baseline
45.65 ± 0.758
41.53 ± 5.27
38.27 ± 0.71
46.02 ± 1.15
39.83 ± 5.30
Week 4
46.94 ± 1.09
38.13 ± 5.28
37.30 ± 0.78
44.31 ± 1.10
37.09 ± 5.27
Week 8
47.45 ± 1.15
34.33 ± 5.18
36.37 ± 2.66
38.51 ± 3.35
35.88 ± 3.92
Week 12
47.25 ± 0.45
28.27 ± 7.21
47.93 ± 2.51
53.78 ± 3.45
55.05 ± 1.26
G1: normal control, G2: hypercholesterolemic control, G3: simvastatin-treated (10 mg/kg), G4: B. alba extract-treated (100 mg/kg), and G5: B. alba extract-treated (200 mg/kg). All data are presented as the mean ± SD ( for each group). One-way ANOVA was performed followed by Dunnett’s post hoc test for multiple comparisons. Within a week, values sharing the same superscript letters are not significantly different from each other ( < 0.05).
