Research Article
Hypoglycemic Effect of Aqueous and Methanolic Extract of Artemisia afra on Alloxan Induced Diabetic Swiss Albino Mice
Table 1
Acute toxicity of
Artemisia afra aqueous extract in Swiss albino mice (
).
| | Dose of A. afra aqueous extract in mg/Kg |
Number of mice per
group () |
Number of mice dead
and percent dead | Signs of toxicity |
| | 0.00 mg/Kg | Group-1 | M = 3 | 0/3 | 0% | None | | F = 3 | 0/3 |
| | 1000 mg/Kg | Group-2 | M = 3 | 0/3 | 0% | None | | F = 3 | 0/3 |
| | 2000 mg/Kg | Group-3 | M = 3 | 0/3 | 0% | None | | F = 3 | 0/3 |
| | 3000 mg/Kg | Group-4 | M = 3 | 0/3 | 0% | None | | F = 3 | 0/3 |
| | 4000 mg/Kg | Group-5 | M = 3 | 0/3 | 0% | None | | F = 3 | 0/3 |
| | 5000 mg/Kg | Group-6 | M = 3 | 0/3 | 0% | Hypoactivity, piloerection | | F = 3 | 0/3 |
| | 7500 mg/Kg | Group-7 | M = 3 | 1/3 | 16.6% | Hypoactivity, piloerection | | F = 3 | 0/3 |
| | 10000 mg/Kg | Group-8 | M = 3 | 1/3 | 33.3% | Hyperventilation, hypoactivity, and salivation | | F = 3 | 1/3 |
| | 12000 mg/Kg | Group-9 | M = 3 | 3/3 | 100% | Convulsion, hyperventilation, hypoactivity, and salivation | | F = 3 | 3/3 |
|
|
