Inhibitory Effects of Cytosolic Ca²⁺ Concentration by Ginsenoside Ro Are Dependent on Phosphorylation of IP₃RI and Dephosphorylation of ERK in Human Platelets

Figure 2

Effects of G-Ro on thrombin-induced human platelet aggregation. (a) The concentration threshold of thrombin on human platelet aggregation. (b) Effects of G-Ro on thrombin-induced human platelet aggregation. (c) The inhibitory effects of G-Ro on thrombin-induced human platelet aggregation. (d) The IC₅₀ value of G-Ro in thrombin-stimulated human platelet aggregation. Measurement of platelet aggregation was carried out as described in “Section 2.” The rate of inhibition by G-Ro was recorded as the percentage of the thrombin-induced aggregation rate. The IC₅₀ value of G-Ro was calculated according to the 4-parameter log fit method. The data are expressed as the mean ± standard deviation (). versus the thrombin-stimulated human platelets.

(a)

(b)

(c)

(d)