Research Article
Sea Buckthorn Leaf Extract Protects Jejunum and Bone Marrow of 60Cobalt-Gamma-Irradiated Mice by Regulating Apoptosis and Tissue Regeneration
Figure 2
(a) Effects of one-time administration of SBL-1 (30 mg/kg b.w.) 30 min before whole body irradiation (10 Gy), on gross histology of mouse jejunum on Day 2, Day 5, Day 10, Day 15, and Day 30. All the irradiated (10 Gy) animals died by Day 12; in SBL-1 + 10 Gy group 94% of the animals survived, while no death was observed in mice treated with SBl-1 alone [8]. (b) The quantitative changes in the villi height, villus cellularity, and cryptal Paneth cell count from Day 2 till Day 30. (c) The typical radioprotective effects of SBL-1 on Day 5 in terms of jejunal lumen size, villi height, villus and crypt cellularity, and cryptal apoptotic and Paneth cells. (d) Quantitative changes in cryptal apoptotic cells and levels of Bcl2 and Bax proteins on Day 5.
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