Evidence-Based Complementary and Alternative Medicine / 2015 / Article / Tab 2

Review Article

Overcome Cancer Cell Drug Resistance Using Natural Products

Table 2

Natural products that can overcome drug resistance and inhibit drug transporters.

Compound nameDoseDrug target1Cell modelChemodrugIDS2Reference

Single compound
 Apigenin15 μMMDR1HCT/5FU5-Fluorouracil5.8[79]
 Arsenic Trioxide0.15–0.4 μMMDR1 and MRPVariousVarious2.1–3.0[8082]
 Artemisinin40 μMMDR1MCF7/ADRDoxorubicin3.6[83]
 Artesunate20 μg/mLMDR1SP2/0/ADMDoxorubicin4.2[84]
 Baicalin20–300 μg/mLMDR1 and MRP1VariousDoxorubicin6.3–7.8[85, 86]
 Berbamine20 μMMDR1 MCF7/ADRDoxorubicin28.3[87]
 Berberine20 μMMDR1HCT8/VCRVincristine3.6[88]
 Carnosic acid5 μg/mLMDR1 K562/A02Doxorubicin12.1[89]
 Chelerythrine0.1 μMMDR1MCF7/TaxelPaclitaxel5.9[90]
 Curcumin2.5–25 μMMDR1 VariousVarious4.6–4.8[91, 92]
 Elemene4–18 μg/mLMDR1 and MRPVariousVarious3.1–4.1[9395]
 Ephedrine75 μg/mLMDR1K562/A02Daunorubicin5.7[96]
 Epigallocatechin gallate2–80 μMMDR1 and ABCG2VariousVarious2.7–24.2[97, 98]
 Gambogic acid4 μg/mLMDR1 SW480/L-OHPOxaliplatin3.7[99]
 Ginsenoside Rb180 μMMDR1HL60/VCRVincristine2.7[100]
 Ginsenoside Rg310–40 μg/mLMDR1, MRP, and LRPVariousVarious7.3–11[101, 102]
 Neferine10–20 μMMDR1 and MRPSGC7901/VCRVarious3.3–43.8[103105]
 Oridonin3 μMMDR1 K562/A02Various9.2[106]
 Oxymatrine0.8 mg/mLMDR1 MCF7/ADMDoxorubicin3.3[107]
 Peimine400 μg/mLLRPA549/DDPCisplatin3.7[108]
 Psoralen20 μg/mLMDR1MCF7/ADRDoxorubicin11.8[109]
 QuercetinVariousMDR1 and MRP1VariousVarious2.3–22.0[110, 111]
 Sodium norcantharidate5 μg/mLMDR1 and MRPA549/DPPCisplatin2.0[112]
 Tetramethylpyrazine200–320 μg/mLMDR1 VariousDoxorubicin2.1–5.2[113115]
 Tetrandrine1 μMMDR1 Hep3B/ADMDoxorubicin12.7[116]
Single herbal extract
Brucea Javanica55.3–125 μg/mLMDR1 and MRPVariousVarious2.1–5.8[117, 118]
 Cinobufacini?MDR1 and MRP1 Raji/ADRDoxorubicin255.7[119]
 Grape seed polyphenols2.4–6.0 μg/mLMDR1 VariousVarious3.4–4.5[120, 121]
 Hyaluronate Oligomers100 μg/mLMDR1 and MRPMCF7/ADMDoxorubicin2.0[122]
 Jew ear8–10 μg/mLMDR1 and MRPVariousVarious2.2–5.6[123125]
Radix notoginseng200 μg/mLMDR1 VariousVarious5.6[126, 127]
Rhizoma pinelliae6.5 μg/mLMDR1K562/A02Doxorubicin3.6[128]
 Realgar25 μg/mLMDR1MCF7/ADMDoxorubicin2.8[129]
Thallus laminariae70–78 μg/mLMDR1VariousDoxorubicin4.7–5.0[130, 130]

Levels of protein or mRNA or both were quantified.
IDS, increase in drug sensitivity (-fold).
IDS = IC50 in control group/IC50 in experimental group.