Evidence-Based Complementary and Alternative Medicine / 2015 / Article / Tab 3

Review Article

Overcome Cancer Cell Drug Resistance Using Natural Products

Table 3

Natural products that can overcome drug resistance and inhibit apoptosis signaling.

Compound nameDose Drug target1Model cellChemodrugIDS2Reference

Single compound
 Curcumin10 μMCaspase-3HCT8/5FU5-Fluorouracil10.1[131]
 Dihydroartemisinin230 nMBcl-2, Bax, and Caspase-3A549/DDPCisplatin8.3[132]
 Elemene10–30 μg/mLGSH, Bcl-2, and BadVariousVarious2.2–3.7[133135]
 Emodin30 μMp-EGFR and p-ERKHCC827/GRGefitinib6.0[136]
 Epigallocatechin gallate80 μMBcl-2 and BaxK562/A02Doxorubicin24.2[137]
 Ginsenoside Rh210 μMA549/DDPCisplatin3.5[138]
 Neferine10 μMBcl-2SGC7901/VCRVincristine43.8[139]
 Parthenolide20 μMSurvivin and Bcl-2A549/GRGefitinib8.7[140]
 Phenylpropanoid glycoside40 μg/mLCaspase-3LoVo/ADRDoxorubicin9.9[141]
 Retinoic acid1 μMBcl-2MCF7/TAMTamoxifen6.7[142]
 Tetrandrine1.0 μg/mLBcl-2 and BaxBIU-87/ADMDoxorubicin2.2[143]
Herbal extract
 Realgar15 μg/mLBcl-2MCF7/ADMDoxorubicin2.3[144]

Levels of protein or mRNA or both were quantified.
IDS, increase in drug sensitivity (-fold).
IDS = IC50 in control group/IC50 in experimental group.