Overcome Cancer Cell Drug Resistance Using Natural Products

Table 4

Natural products that can overcome drug resistance and regulate multiple pathways.

Compound name	Dose	Pathways^1	Cell model	Chemodrug	IDS^2	Reference
Single compound
Arsenic trioxide	0.8 μM	MDR1 and GST-π	SGC7901/ADR	Doxorubicin	2.1	[82]
Berbamine	20 μM	MDR1 and survivin	K562/A02	Doxorubicin	41.2	[145]
Carnosic acid	25 μM	MDR1 and Bcl-2	K562/A02	Doxorubicin	12.1	[146]
Curcumin	25 μM	MRP and Bcl-2	HL60/ADR	Doxorubicin	4.2	[147]
Emodin	10 μM	MRP1, Topo II b, GST-π, and Bcl-2	HL60/ADR	Doxorubicin	4.1	[148]
Honokiol	6.5 μg/mL	MDR1 and NFkB	U937/ADR	Doxorubicin	2.2	[149]
Methylether-scutellarein	20 μg/mL	ABC and apoptosis genes	JAR/VP16	Various	2.5–5.0	[150]
Quercetin	10 μg/mL	MDR1 and survivin	A549/DDP	Cisplatin	3.5	[151]
Quercetin	40 μM	ABC, Bcl-2, and SLC genes	K562/A	Doxorubicin	3.7	[152]
Quercetin	40 μM	MDR1, MRP, GST-π, and H-ras	Bel-FU	5-Fluorouracil	2.4	[153]
Schizandrin B	10 μM	MDR1, pPI3K, and pAKT	U-2 OS/ADR	Various	2.3–2.9	[154]
Schizandrin A	50 μM	MDR1 and GSH	Various	Various	41.2–147.5	[155]
Sodium selenite	10 μM	MDR and Bcl-2	K562/ADR	Doxorubicin	2.3	[156]
Tetrandrine	1 μg/mL	MDR1, survivin, and caspase-3	BIU87/ADM	Doxorubicin	5.3	[157]
Herbal extract
Radix bupleuri	300 μg/mL	MDR1 and TopoIIα	Bel-7402	Verapamil	15.6	[158]
Grape seed polyphenols	6 μg/mL	MDR1 and Bcl-2	GBC/SD	Various	3.4–4.5	[159]
Tea polyphenols	7.5 μg/mL	MRP and Bcl-2	HL60/VCR	Various	2.3–9.1	[160]

Levels of protein or mRNA or both were quantified.
IDS, increase in drug sensitivity (-fold).
IDS = IC50 in control group/IC50 in experimental group.