Overcome Cancer Cell Drug Resistance Using Natural Products

Table 5

Natural products overcome drug resistance in serum pharmacology studies.

Name	Dose (days)	Serum dose^1	Cell model	Chemodrug	IDS^2	Reference
Buzhong Yiqi Tang	5.7 g/kg (3)	15	A549/DDP	Cisplatin	3	[161]
Jiedu Huayu recipe	3 g/kg (3)	10	HL60/Adr	Doxorubicin	8.4	[162]
Scutellariae barbatae	14.1 g/kg (4)	0.5	K562/A02	Various	2.2–5.4	[163]
Shehuang Xiaoliu	29.7 g/kg (10)	20	Bel7402	Doxorubicin	8.3	[164]
Zedoary turmeric oil	0.8 mg/kg (3)	20	SGC7901/CDDP	Verapamil	6.1	[165]

Percentage of serum being tested in addition to the conventional 10% of fetal bovine serum in cell culture.
IDS, increase in drug sensitivity (-fold).
IDS = IC50 in control group/IC50 in experimental group.