Evidence-Based Complementary and Alternative Medicine / 2015 / Article / Tab 5

Review Article

Overcome Cancer Cell Drug Resistance Using Natural Products

Table 5

Natural products overcome drug resistance in serum pharmacology studies.

Name Dose (days)Serum dose1Cell modelChemodrugIDS2Reference

Buzhong Yiqi Tang5.7 g/kg (3)15A549/DDPCisplatin3[161]
Jiedu Huayu recipe3 g/kg (3)10HL60/AdrDoxorubicin8.4[162]
Scutellariae barbatae14.1 g/kg (4)0.5K562/A02Various2.2–5.4[163]
Shehuang Xiaoliu 29.7 g/kg (10)20Bel7402Doxorubicin8.3[164]
Zedoary turmeric oil0.8 mg/kg (3)20SGC7901/CDDPVerapamil6.1[165]

Percentage of serum being tested in addition to the conventional 10% of fetal bovine serum in cell culture.
IDS, increase in drug sensitivity (-fold).
IDS = IC50 in control group/IC50 in experimental group.