Evidence-Based Complementary and Alternative Medicine / 2015 / Article / Tab 6

Review Article

Overcome Cancer Cell Drug Resistance Using Natural Products

Table 6

Clinical studies and benefits.

Disease (number of patients)Treatment agentClinical benefitReference

Relapsed non-Hodgkin’s lymphoma (60)LigustrazineHigher overall response rate[166]

Breast cancer (76)Chinese magnolcavine fruitIncrease in response rate, delayed remission, and increase in the MRP negativity rate[167]

Advanced gastrointestinal cancer (54)Changweiqing formulaHigher response rate and Karnofsky score
Longer survival time
Lower level of MDR1 in blood cells
[168]

Gastric cancer, stages II-III (30)Didang formulaHigher response rate and better life quality
Lower level of MDR1 in blood cells
[169]

Liver cancer (71)Xiaochaihu formulaHigher response rate and lower protein level of MDR1 in cancer tissue[170]

Gastric cancer, stages II-III (60)Shenqi Jianwei formulaHigher response rate, lower level of lower of CEA, and higher Karnofsky score[171]

Breast cancer (60)Pingxiao formulaHigher response rate and lower protein levels of MDR1 and GSTπ in cancer tissues[172]

Breast cancer (53)Fukangling capsuleHigher response rate and lower protein levels of MDR1 and GSTπ in cancer tissues[173]

Non-small cell lung cancer (60)Qiankun capsuleLower level of blood TGF-α and lower number of PCNA positive cells as well as lower protein levels of LRP and MRP in cancer tissue[174]

Breast cancer, stages II-III (33)Fukangling capsuleHigher response rate and lower protein level of MDR1 in cancer tissue[174]