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Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 782742, 8 pages
http://dx.doi.org/10.1155/2015/782742
Research Article

Antithrombotic Effects of Five Organic Extracts of Bangladeshi Plants In Vitro and Mechanisms in In Silico Models

1Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh
2Bangladesh Forest Research Institute, Chittagong 4000, Bangladesh
3Department of Pharmacy, BGC Trust University, Chittagong 4000, Bangladesh

Received 21 January 2015; Revised 6 March 2015; Accepted 12 March 2015

Academic Editor: Feng-Qing Yang

Copyright © 2015 Sakib Mahmud et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This research was carried out to investigate the thrombolytic effects of the methanolic extracts of five Bangladeshi plants. Phytochemical metabolites of those plants have been identified to elucidate whether the plant-derived metabolites are linked with the thrombolytic effects. Potential computer aided models were adopted in this study to find out a structure-function correlation between the phytochemical constituents and thrombolytic effects using the secondary metabolites as ligands and tissue plasminogen activator (t-PA) as receptor for the best fit ligand-receptor interaction.