Aortic Remodelling Is Improved by 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside Involving the Smad3 Pathway in Spontaneously Hypertensive Rats

Figure 1

THSG improved vascular wall thickening in rat aortas. (a) Haematoxylin and eosin (H&E) staining for aortal sections from WKY rats, SHRs, and SHRs treated with THSG. (b) The media thickness of aortas from WKY rats, SHRs, and SHRs treated with THSG (). (c) ACh induced an endothelium-dependent relaxation at the indicated dose in PE precontracted rat aortic rings (). The maximum vasodilation by sodium nitroprusside (50 μmol/L) was considered as 100%. Data are expressed as the mean ± SEM. versus WKY; versus SHRs.

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