Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 790739, 12 pages
http://dx.doi.org/10.1155/2015/790739
Research Article

The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF-κB Pathway in Mice

1Department of Chinese Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200092, China
2Institute of Chinese Medicine, Tongji University School of Medicine, Shanghai 200092, China
3Department of Biosynthesis, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China

Received 4 May 2014; Revised 22 September 2014; Accepted 23 September 2014

Academic Editor: Yi-tao Wang

Copyright © 2015 Lijuan Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. K. Louie, M. Acosta, K. Winter et al., “Factors associated with death or hospitalization due to pandemic 2009 influenza A(H1N1) infection in California,” The Journal of the American Medical Association, vol. 302, no. 17, pp. 1896–1902, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. K. A. Shirey, W. Lai, A. J. Scott et al., “The TLR4 antagonist Eritoran protects mice from lethal influenza infection,” Nature, vol. 497, no. 7450, pp. 498–502, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. D. Wang, Y. Hu, J. Sun, X. Kong, B. Zhang, and J. Liu, “Comparative study on adjuvanticity of compound Chinese herbal medicinal ingredients,” Vaccine, vol. 23, no. 28, pp. 3704–3708, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. C.-C. Yeh, C.-C. Lin, S.-D. Wang et al., “Protective and immunomodulatory effect of Gingyo-san in a murine model of acute lung inflammation,” Journal of Ethnopharmacology, vol. 111, no. 2, pp. 418–426, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. C.-H. Hsu, K.-C. Hwang, C.-L. Chao et al., “An evaluation of the additive effect of natural herbal medicine on SARS or SARS-like infectious diseases in 2003: a randomized, double-blind, and controlled pilot study,” Evidence-Based Complementary and Alternative Medicine, vol. 5, no. 3, pp. 355–362, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. W. Chen, C. E. D. Lim, H.-J. Kang, and J. Liu, “Chinese herbal medicines for the treatment of type A H1N1 influenza: a systematic review of randomized controlled trials,” PLoS ONE, vol. 6, no. 12, Article ID e28093, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. N. L. la Gruta, K. Kedzierska, J. Stambas, and P. C. Doherty, “A question of self-preservation: immunopathology in influenza virus infection,” Immunology and Cell Biology, vol. 85, no. 2, pp. 85–92, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. D. Kobasa, S. M. Jones, K. Shinya et al., “Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus,” Nature, vol. 445, no. 7125, pp. 319–323, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. D. M. Tscherne and A. García-Sastre, “Virulence determinants of pandemic influenza viruses,” The Journal of Clinical Investigation, vol. 121, no. 1, pp. 6–13, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. T.-N. Nguyen-Pham, M.-S. Lim, T. A. T. Nguyen et al., “Type I and II interferons enhance dendritic cell maturation and migration capacity by regulating CD38 and CD74 that have synergistic effects with TLR agonists,” Cellular & Molecular Immunology, vol. 8, no. 4, pp. 341–347, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. S. Bae, J. H. Lee, S. H. Choi et al., “Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2,” Circulation Research, vol. 104, no. 2, pp. 210–218, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Hirayama, Y. Tamaki, Y. Takakubo et al., “Toll-like receptors and their adaptors are regulated in macrophages after phagocytosis of lipopolysaccharide-coated titanium particles,” Journal of Orthopaedic Research, vol. 29, no. 7, pp. 984–992, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. A. A. I. Fooladi, S. F. Mousavi, S. Seghatoleslami, S. Yazdani, and M. R. Nourani, “Toll-like receptors: role in inflammation and commensal bacteria,” Inflammation & Allergy-Drug Targets, vol. 10, no. 3, pp. 198–207, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. K. Takeda and S. Akira, “Toll-like receptors in innate immunity,” International Immunology, vol. 17, no. 1, pp. 1–14, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Akira and K. Takeda, “Toll-like receptor signalling,” Nature Reviews Immunology, vol. 4, no. 7, pp. 499–511, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. W. Barchet, A. Krug, M. Cella et al., “Dendritic cells respond to influenza virus through TLR7- and PKR-independent pathways,” European Journal of Immunology, vol. 35, no. 1, pp. 236–242, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. L. Chen, J. Fan, Y. Li et al., “Modified Jiu Wei Qiang Huo decoction improves dysfunctional metabolomics in influenza A pneumonia-infected mice,” Biomedical Chromatography, vol. 28, no. 4, pp. 468–474, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. M.-H. Ji, G.-M. Li, M. Jia et al., “Valproic acid attenuates lipopolysaccharide-induced acute lung injury in mice,” Inflammation, vol. 36, no. 6, pp. 1453–1459, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. C. Cillóniz, K. Shinya, X. Peng et al., “Lethal influenza virus infection in macaques is associated with early dysregulation of inflammatory related genes,” PLoS Pathogens, vol. 5, no. 10, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. P. Tseng, Y. C. Wu, Y. L. Leu, S. F. Yeh, and C. K. Chou, “Scutellariae radix suppresses hepatitis B virus production in human hepatoma cells,” Frontiers in Bioscience, vol. 2, no. 4, pp. 1538–1547, 2010. View at Google Scholar · View at Scopus
  21. J. Dou, L. Chen, G. Xu et al., “Effects of baicalein on Sendai virus in vivo are linked to serum baicalin and its inhibition of hemagglutinin-neuraminidase,” Archives of Virology, vol. 156, no. 5, pp. 793–801, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. Q. Zhang, B. Yang, N. Wang, L. Duan, S. He, and J. Sun, “Effect of total flavonoids of Scutellaria baicalensis Georgi on expression of influenza A virus nucleoprotein in HeLa cells,” Nan Fang Yi Ke Da Xue Xue Bao, vol. 32, no. 7, pp. 966–969, 2012. View at Google Scholar · View at Scopus
  23. X.-W. Yang, Z.-M. Gu, B.-X. Wang, M. Hattori, and T. Namba, “Comparison of anti-lipid peroxidative effects of the underground parts of Notopterygium incisum and N. forbesii in mice,” Planta Medica, vol. 57, no. 5, pp. 399–402, 1991. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Zheng, “Experimental study of 472 herbs with antiviral action against the herpes simplex virus,” Chinese Journal of Modern Developments in Traditional Medicine, vol. 10, no. 1, pp. 39–41, 1990. View at Google Scholar · View at Scopus
  25. G. Ye, Y.-H. Tang, G.-X. Xia, Z.-L. Sun, Z.-X. Li, and C.-G. Huang, “Characterization of anti-Coxsackie virus B3 constituents of Radix Astragali by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry,” Biomedical Chromatography, vol. 24, no. 11, pp. 1147–1151, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Wang, J. Li, H. Huang et al., “Anti-hepatitis B virus activities of astragaloside IV isolated from Radix Astragali,” Biological and Pharmaceutical Bulletin, vol. 32, no. 1, pp. 132–135, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. Z. Q. Zhang, Y. J. Tian, and J. Zhang, “Studies on the antioxidative activity of polysaccharides from radix Saposhnikoviae,” Zhong Yao Cai, vol. 31, no. 2, pp. 268–272, 2008. View at Google Scholar
  28. N. Inagaki, Y. Komatsu, H. Sasaki et al., “Acidic polysaccharides from rhizomes of Atractylodes lancea as protective principle in Candida-infected mice,” Planta Medica, vol. 67, no. 5, pp. 428–431, 2001. View at Publisher · View at Google Scholar · View at Scopus
  29. K. Taguchi, Y. Hagiwara, K. Kajiyama, and Y. Suzuki, “Pharmacological studies of Houttuyniae Herba: the anti-inflammatory effect of quercitrin,” Yakugaku Zasshi, vol. 113, no. 4, pp. 327–333, 1993. View at Google Scholar · View at Scopus
  30. S. Li, R. Wang, Y. Zhang et al., “Symptom combinations associated with outcome and therapeutic effects in a cohort of cases with SARS,” American Journal of Chinese Medicine, vol. 34, no. 6, pp. 937–947, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. J.-H. Wang, H.-L. Nie, S.-C. Tam, H. Huang, and Y.-T. Zheng, “Anti-HIV-1 property of trichosanthin correlates with its ribosome inactivating activity,” FEBS Letters, vol. 531, no. 2, pp. 295–298, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. J.-H. Wang, H.-L. Nie, H. Huang, S.-C. Tam, and Y.-T. Zheng, “Independency of anti-HIV-1 activity from ribosome-inactivating activity of trichosanthin,” Biochemical and Biophysical Research Communications, vol. 302, no. 1, pp. 89–94, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. L. Xu, L. Bao, F. Li et al., “Adaption of seasonal H1N1 influenza virus in mice,” PLoS ONE, vol. 6, no. 12, Article ID e28901, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. C. L. Speyer and P. A. Ward, “Role of endothelial chemokines and their receptors during inflammation,” Journal of Investigative Surgery, vol. 24, no. 1, pp. 18–27, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. R. V. D'elia, K. Harrison, P. C. Oyston, R. A. Lukaszewski, and G. C. Clark, “Targeting the “cytokine storm” for therapeutic benefit,” Clinical and Vaccine Immunology, vol. 20, no. 3, pp. 319–327, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. S. Matsukura, F. Kokubu, H. Kubo et al., “Expression of RANTES by normal airway epithelial cells after influenza virus A infection,” American Journal of Respiratory Cell and Molecular Biology, vol. 18, no. 2, pp. 255–264, 1998. View at Publisher · View at Google Scholar · View at Scopus
  37. F. G. Hayden, R. S. Fritz, M. C. Lobo, W. G. Alvord, W. Strober, and S. E. Straus, “Local and systemic cytokine responses during experimental human influenza A virus infection. Relation to symptom formation and host defense,” The Journal of Clinical Investigation, vol. 101, no. 3, pp. 643–649, 1998. View at Publisher · View at Google Scholar · View at Scopus
  38. L. Kaiser, R. S. Fritz, S. E. Straus, L. Gubareva, and F. G. Hayden, “Symptom pathogenesis during acute influenza: interleukin-6 and other cytokine responses,” Journal of Medical Virology, vol. 64, no. 3, pp. 262–268, 2001. View at Publisher · View at Google Scholar · View at Scopus
  39. J. Sirén, T. Sareneva, J. Pirhonen et al., “Cytokine and contact-dependent activation of natural killer cells by influenza A or Sendai virus-infected macrophages,” Journal of General Virology, vol. 85, no. 8, pp. 2357–2364, 2004. View at Publisher · View at Google Scholar · View at Scopus
  40. C. L. Galligan, T. T. Murooka, R. Rahbar, E. Baig, B. Majchrzak-Kita, and E. N. Fish, “Interferons and viruses: signaling for supremacy,” Immunologic Research, vol. 35, no. 1-2, pp. 27–40, 2006. View at Publisher · View at Google Scholar · View at Scopus
  41. A. Billiau, H. Heremans, K. Vermiere, and P. Matthys, “Immunomodulatory properties of interferon-γ. An update,” Annals of the New York Academy of Sciences, vol. 856, pp. 22–32, 1998. View at Publisher · View at Google Scholar · View at Scopus
  42. J. R. Teijaro, K. B. Walsh, S. Cahalan et al., “Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection,” Cell, vol. 146, no. 6, pp. 980–991, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. H. Sprenger, R. G. Meyer, A. Kaufmann, D. Bussfeld, E. Rischkowsky, and D. Gemsa, “Selective induction of monocyte and not neutrophil-attracting chemokines after influenza A virus infection,” Journal of Experimental Medicine, vol. 184, no. 3, pp. 1191–1196, 1996. View at Publisher · View at Google Scholar · View at Scopus
  44. V. A. Arankalle, K. S. Lole, R. P. Arya et al., “Role of host immune response and viral load in the differential outcome of pandemic H1N1 (2009) influenza virus infection in indian patients,” PLoS ONE, vol. 5, no. 10, Article ID e13099, 2010. View at Publisher · View at Google Scholar · View at Scopus
  45. H. Hemmi, T. Kaisho, O. Takeuchi et al., “Small-antiviral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway,” Nature Immunology, vol. 3, no. 2, pp. 196–200, 2002. View at Publisher · View at Google Scholar · View at Scopus
  46. J. M. Lund, L. Alexopoulou, A. Sato et al., “Recognition of single-stranded RNA viruses by Toll-like receptor 7,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 15, pp. 5598–5603, 2004. View at Publisher · View at Google Scholar · View at Scopus
  47. S. S. Diebold, T. Kaisho, H. Hemmi, S. Akira, and C. R. e Sousa, “Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA,” Science, vol. 303, no. 5663, pp. 1529–1531, 2004. View at Publisher · View at Google Scholar · View at Scopus
  48. K. Takeda and S. Akira, “TLR signaling pathways,” Seminars in Immunology, vol. 16, no. 1, pp. 3–9, 2004. View at Publisher · View at Google Scholar · View at Scopus
  49. H. L. Pahl, “Activators and target genes of Rel/NF-κB transcription factors,” Oncogene, vol. 18, no. 49, pp. 6853–6866, 1999. View at Publisher · View at Google Scholar · View at Scopus
  50. S. E. Dudek, C. Luig, E.-K. Pauli, U. Schubert, and S. Ludwig, “The clinically approved proteasome inhibitor PS-341 efficiently blocks influenza A virus and vesicular stomatitis virus propagation by establishing an antiviral state,” Journal of Virology, vol. 84, no. 18, pp. 9439–9451, 2010. View at Publisher · View at Google Scholar · View at Scopus
  51. E. Haasbach, E.-K. Pauli, R. Spranger et al., “Antiviral activity of the proteasome inhibitor VL-01 against influenza A viruses,” Antiviral Research, vol. 91, no. 3, pp. 304–313, 2011. View at Publisher · View at Google Scholar · View at Scopus
  52. I. Mazur, W. J. Wurzer, C. Ehrhardt et al., “Acetylsalicylic acid (ASA) blocks influenza virus propagation via its NF-κB-inhibiting activity,” Cellular Microbiology, vol. 9, no. 7, pp. 1683–1694, 2007. View at Publisher · View at Google Scholar · View at Scopus
  53. C. E. van der Sandt, J. H. C. M. Kreijtz, and G. F. Rimmelzwaan, “Evasion of influenza A viruses from innate and adaptive immune responses,” Viruses, vol. 4, no. 9, pp. 1438–1476, 2012. View at Publisher · View at Google Scholar · View at Scopus
  54. Z. Cao, J. Xiong, M. Takeuchi, T. Kurama, and D. V. Goeddel, “TRAF6 is a signal transducer for interleukin-1,” Nature, vol. 383, no. 6599, pp. 443–446, 1996. View at Publisher · View at Google Scholar · View at Scopus
  55. E. Kopp and R. Medzhitov, “Recognition of microbial infection by Toll-like receptors,” Current Opinion in Immunology, vol. 15, no. 4, pp. 396–401, 2003. View at Publisher · View at Google Scholar · View at Scopus
  56. S. Akira and S. Sato, “Toll-like receptors and their signaling mechanisms,” Scandinavian Journal of Infectious Diseases, vol. 35, no. 9, pp. 555–562, 2003. View at Publisher · View at Google Scholar · View at Scopus
  57. E. Zandi, D. M. Rothwarf, M. Delhase, M. Hayakawa, and M. Karin, “The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for Iκb phosphorylation and NF-κB activation,” Cell, vol. 91, no. 2, pp. 243–252, 1997. View at Publisher · View at Google Scholar · View at Scopus
  58. S. S. Makarov, “NF-ΚB in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction,” Arthritis Research, vol. 3, no. 4, pp. 200–206, 2001. View at Publisher · View at Google Scholar · View at Scopus