Effect of Keishibukuryogan on Genetic and Dietary Obesity Models

Figure 4

Effect of KBG on liver lipid levels in obesity models. (a) SHR rats were administered with control water or KBG (500 mg/kg, p.o., daily) for 8 weeks. Liver tissue samples were collected upon the termination and levels of triglyceride (TG, left), total cholesterol (cholesterol, middle), and free fatty acid (FAA, right) were measured. (b) C57BL/6 mice were fed with normal diet (ND) or high-fat diet (HFD) for 10 weeks and then administered control water or KBG (500 mg/kg, p.o., daily) for 12 weeks under the same feeding condition. After 8 weeks of control or KBG treatment, mice fed with HFD were changed to ND until the termination of experiment with maintaining KBG treatment for another 4 weeks. Liver tissue samples were collected upon the termination and levels of triglyceride (TG, left), total cholesterol (cholesterol, middle), and free fatty acid (FAA, right) were measured. Data are mean ± SEM ( = 7–15). .

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