Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 801691, 11 pages
http://dx.doi.org/10.1155/2015/801691
Research Article

1H NMR Metabolic Profiling of Biofluids from Rats with Gastric Mucosal Lesion and Electroacupuncture Treatment

1Department of Electronic Science and Department of Traditional Chinese Medicine, Xiamen University, Xiamen 361005, China
2Department of Bioprocess Engineering and Innovation Centre in Agritechnology, Universiti Teknologi Malaysia, 81310 Johor Bahru, Malaysia
3College of Acupuncture and Moxibustion, Hunan University of Traditional Chinese Medicine, Changsha 410000, China

Received 11 February 2015; Accepted 3 April 2015

Academic Editor: Shuhai Lin

Copyright © 2015 Jingjing Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. Murata, A. Oyagi, D. Takahira et al., “Protective effects of astaxanthin from Paracoccus carotinifaciens on murine gastric ulcer models,” Phytotherapy Research, vol. 26, no. 8, pp. 1126–1132, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Shiotani and D. Y. Graham, “Pathogenesis and therapy of gastric and duodenal ulcer disease,” Medical Clinics of North America, vol. 86, no. 6, pp. 1447–1466, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. X. Wang, H. Sun, A. Zhang, W. Sun, P. Wang, and Z. Wang, “Potential role of metabolomics apporoaches in the area of traditional Chinese medicine: as pillars of the bridge between Chinese and Western medicine,” Journal of Pharmaceutical and Biomedical Analysis, vol. 55, no. 5, pp. 859–868, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. Z.-B. Yang, J. Yan, X.-P. Zou et al., “Enhanced expression of epidermal growth factor receptor gene in gastric mucosal cells by the serum derived from rats treated with electroacupuncture at stomach meridian acupoints,” World Journal of Gastroenterology, vol. 12, no. 34, pp. 5557–5561, 2006. View at Google Scholar · View at Scopus
  5. Y. Li, G. Tougas, S. G. Chiverton, and R. H. Hunt, “The effect of acupuncture on gastrointestinal function and disorders,” American Journal of Gastroenterology, vol. 87, no. 10, pp. 1372–1381, 1992. View at Google Scholar · View at Scopus
  6. G. Lux, J. Hagel, P. Bäcker et al., “Acupuncture inhibits vagal gastric acid secretion stimulated by sham feeding in healthy subjects,” Gut, vol. 35, no. 8, pp. 1026–1029, 1994. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Chan, I. Carr, and J. F. Mayberry, “The role of acupuncture in the treatment of irritable bowel syndrome: a pilot study,” Hepato-Gastroenterology, vol. 44, no. 17, pp. 1328–1330, 1997. View at Google Scholar · View at Scopus
  8. Z. Fireman, A. Segal, Y. Kopelman, A. Sternberg, and R. Carasso, “Acupuncture treatment for irritable bowel syndrome: a double-blind controlled study,” Digestion, vol. 64, no. 2, pp. 100–103, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. D. L. Diehl, “Acupuncture for gastrointestinal and hepatobiliary disorders,” Journal of Alternative and Complementary Medicine, vol. 5, no. 1, pp. 27–45, 1999. View at Publisher · View at Google Scholar · View at Scopus
  10. E. Broide, S. Pintov, S. Portnoy, J. Barg, E. Klinowski, and E. Scapa, “Effectiveness of acupuncture for treatment of childhood constipation,” Digestive Diseases and Sciences, vol. 46, no. 6, pp. 1270–1275, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Burgmann, P. Rawsthorne, and C. N. Bernstein, “Predictors of alternative and complementary medicine use in inflammatory bowel disease: do measures of conventional health care utilization relate to use?” American Journal of Gastroenterology, vol. 99, no. 5, pp. 889–893, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. D. Shen, B. Liu, D. Wi, F. Zhang, and Y. Chen, “Effects of electroacupuncture on central and peripheral monoamine neurotransmitter in the course of protecting rat stress peptic ulcer,” Acupuncture Research, vol. 19, no. 1, pp. 51–54, 1994. View at Google Scholar
  13. H. Li, C. Z. Tang, S. H. Li, Z. Zhang, S. J. Chen, and J. W. Zhang, “Effects of thread embedding therapy on nucleotides and gastrointestinal hormones in the patient of chronic gastritis,” Chinese Acupuncture & Moxibustion, vol. 25, no. 5, pp. 301–303, 2005. View at Google Scholar
  14. C.-H. Chang, J.-L. Huang, C.-T. Ting, C.-S. Chang, and G.-H. Chen, “Atropine-induced HRV alteration is not amended by electroacupuncture on Zusanli,” American Journal of Chinese Medicine, vol. 33, no. 2, pp. 307–314, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Coen, E. Holmes, J. C. Lindon, and J. K. Nicholson, “NMR-based metabolic profiling and metabonomic approaches to problems in molecular toxicology,” Chemical Research in Toxicology, vol. 21, no. 1, pp. 9–27, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. J. J. Xu, S. Yang, S. Cai, J. Dong, X. Li, and Z. Chen, “Identification of biochemical changes in lactovegetarian urine using 1H NMR spectroscopy and pattern recognition,” Analytical and Bioanalytical Chemistry, vol. 396, no. 4, pp. 1451–1463, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. A. H. Zhang, H. Sun, Z. Wang, W. Sun, P. Wang, and X. Wang, “Metabolomics: towards understanding traditional Chinese medicine,” Planta Medica, vol. 76, no. 17, pp. 2026–2035, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. G. Yan, A. Zhang, H. Sun et al., “Dissection of biological property of chinese acupuncture point zusanli based on long-term treatment via modulating multiple metabolic pathways,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 429703, 10 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. P. C. Konturek, T. Brzozowski, S. J. Konturek et al., “Activation of genes for growth factors and cyclooxygenases in rat gastric mucosa during recovery from stress damage,” European Journal of Pharmacology, vol. 342, no. 1, pp. 55–65, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. J. K. Nicholson, P. J. D. Foxall, M. Spraul, R. D. Farrant, and J. C. Lindon, “750 MHz 1H and 1H-13C NMR spectroscopy of human blood plasma,” Analytical Biochemistry, vol. 67, no. 5, pp. 793–811, 1995. View at Publisher · View at Google Scholar
  21. S. Meiboom and D. Gill, “Modified spin-echo method for measuring nuclear relaxation times,” Review of Scientific Instruments, vol. 29, no. 8, pp. 688–691, 1958. View at Publisher · View at Google Scholar · View at Scopus
  22. E. Holmes, P. J. D. Foxall, M. Spraul, R. D. Farrant, J. K. Nicholson, and J. C. Lindon, “750 MHz 1H NMR spectroscopy characterisation of the complex metabolic pattern of urine from patients with inborn errors of metabolism: 2-hydroxyglutaric aciduria and maple syrup urine disease,” Journal of Pharmaceutical and Biomedical Analysis, vol. 15, no. 11, pp. 1647–1659, 1997. View at Publisher · View at Google Scholar · View at Scopus
  23. K. M. Åberg, E. Alm, and R. J. O. Torgrip, “The correspondence problem for metabonomics datasets,” Analytical and Bioanalytical Chemistry, vol. 394, no. 1, pp. 151–162, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. F. Dieterle, A. Ross, G. Schlotterbeck, and H. Senn, “Probabilistic quotient normalization as robust method to account for dilution of complex biological mixtures. Application in1H NMR metabonomics,” Analytical Chemistry, vol. 78, no. 13, pp. 4281–4290, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. P. H. Guth, F. Ali, and G. Paulsen, “Chronic antral ulcer shortens cancer induction time in rats,” Gastroenterology, vol. 78, no. 5, p. 1176, 1980. View at Google Scholar
  26. R. C. Pinto, V. Bosc, H. Noçairi, A. S. Barros, and D. N. Rutledge, “Using ANOVA-PCA for discriminant analysis: application to the study of mid-infrared spectra of carraghenan gels as a function of concentration and temperature,” Analytica Chimica Acta, vol. 629, no. 1-2, pp. 47–55, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. R. Climaco-Pinto, A. S. Barros, N. Locquet, L. Schmidtke, and D. N. Rutledge, “Improving the detection of significant factors using ANOVA-PCA by selective reduction of residual variability,” Analytica Chimica Acta, vol. 653, no. 2, pp. 131–142, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. J. G. Xia, N. Psychogios, N. Young, and D. S. Wishart, “MetaboAnalyst: a web server for metabolomic data analysis and interpretation,” Nucleic Acids Research, vol. 37, no. 2, pp. W652–W660, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Xia, R. Mandal, I. V. Sinelnikov, D. Broadhurst, and D. S. Wishart, “MetaboAnalyst 2.0-a comprehensive server for metabolomic data analysis,” Nucleic Acids Research, vol. 40, no. 1, pp. W127–W133, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. K. Takeuchi, M. Ohishi, S. Ota et al., “Metabolic profiling to identify potential serum biomarkers for gastric ulceration induced by nonsteroid anti-inflammatory drugs,” Journal of Proteome Research, vol. 12, no. 3, pp. 1399–1407, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. K. Takeuchi, M. Ohishi, K. Endo et al., “Metabolomic analysis of the effects of omeprazole and famotidine on aspirin-induced gastric injury,” Metabolomics, vol. 10, no. 5, pp. 995–1004, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. K. G. Sim, J. Hammond, and B. Wilcken, “Strategies for the diagnosis of mitochondrial fatty acid β-oxidation disorders,” Clinica Chimica Acta, vol. 323, no. 1-2, pp. 37–58, 2002. View at Publisher · View at Google Scholar · View at Scopus
  33. S. J. Gatley and H. S. A. Sherratt, “The synthesis of hippurate from benzoate and glycine by rat liver mitochondria. Submitochondrial localization and kinetics,” Biochemical Journal, vol. 166, no. 1, pp. 39–47, 1977. View at Google Scholar · View at Scopus
  34. G. C. Tremblay and I. A. Qureshi, “The biochemistry and toxicology of benzoic acid metabolism and its relationship to the elimination of waste nitrogen,” Pharmacology & Therapeutics, vol. 60, no. 1, pp. 63–90, 1993. View at Publisher · View at Google Scholar
  35. D. O. Yang, J. Xu, H. Huang, and Z. Chen, “Metabolomic profiling of serum from human pancreatic cancer patients using 1H NMR spectroscopy and principal component analysis,” Applied Biochemistry and Biotechnology, vol. 165, no. 1, pp. 148–154, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Iwa, M. Tateiwa, M. Sakita, M. Fujimiya, and T. Takahashi, “Anatomical evidence of regional specific effects of acupuncture on gastric motor function in rats,” Autonomic Neuroscience: Basic & Clinical, vol. 137, no. 1-2, pp. 67–76, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. W.-X. Niu, G.-D. He, H. Liu, and X.-Y. Qin, “Effects and probable mechanisms of electroacupuncture at the Zusanli point on upper gastrointestinal motility in rabbits,” Journal of Gastroenterology and Hepatology, vol. 22, no. 10, pp. 1683–1689, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. Y. Zhang, A. Zhang, G. Yan et al., “High-throughput metabolomic approach revealed the acupuncture exerting intervention effects by perturbed signatures and pathways,” Molecular BioSystems, vol. 10, no. 1, pp. 65–73, 2014. View at Publisher · View at Google Scholar · View at Scopus