Antihypertensive Effect of the GaMiSamHwangSaSimTang in Spontaneous Hypertensive Rats

Figure 3

Effect of HVC1 on endothelium-intact aortic rings preincubated with ω-Nitro-L-arginine methyl ester (L-NAME, 10 μM) or methylene blue (MB, 10 μM). The graph shows the relaxation responses induced by HVC1 in endothelium-intact spontaneous hypertensive rat aortic rings that had been precontracted with phenylephrine (PE, 1 μM) in the presence or absence of L-NAME or MB in Krebs-Henseleit solution. The relaxant effects of HVC1 on isolated spontaneous hypertensive rat aortic rings were calculated as a percentage of the contraction in response to PE. Values are expressed as mean ± SEM (). and versus HVC1.