Adenosine A2A Receptors Mediate Anti-Inflammatory Effects of Electroacupuncture on Synovitis in Mice with Collagen-Induced Arthritis

Figure 4

Histology of knee joints of mice with CIA. Histological evaluation of knee joints from CIA-control mice revealed signs of severe arthritis, with inflammatory cell infiltration, cartilage damage, and bone erosion compared to normal mice in the Sham-control group (a, b, and f). Histological joint alterations were significantly reduced in tissues from CIA-EA mice (c, f). The joint histology was not significantly different in either CIA-EA-SCH58261 mice or CIA-SCH58261 mice compared to CIA-control mice (b, d, e, and f). Values are means ± SEM of 10 animals for each group. versus Sham-control. ^Δ versus CIA-control. ^# versus CIA-EA. Magnification ×200.

(a)   Sham-control

(b) CIA-control

(c) CIA-EA

(d) CIA-EA-SCH58261

(e) CIA-SCH58261

(f)