Protective Effect of Triptolide against Glomerular Mesangial Cell Proliferation and Glomerular Fibrosis in Rats Involves the TGF-<i>β</i>1/Smad Signaling Pathway

<div>The effect of triptolide on the subcellular localization of the Smad3 and Ski proteins of the TGF-<i>β</i>1-induced RMC. In control group, Smad3 protein was mainly expressed in the cytoplasm but, in the TGF-<i>β</i>1-induced group, the level of expression of Smad3 protein was significantly higher and was mainly localized in the nucleus. Ski protein of the control group was expressed mainly in the nucleus. The level of expression of Ski in and out of the nucleus of the TGF-<i>β</i>1-induced group was significantly higher and was mainly localized in the cytoplasm (bar = 75 <i>μ</i>m).</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 4: Protective Effect of Triptolide against Glomerular Mesangial Cell Proliferation and Glomerular Fibrosis in Rats Involves the TGF-<i>β</i>1/Smad Signaling Pathway 

Figure 4 | Protective Effect of Triptolide against Glomerular Mesangial Cell Proliferation and Glomerular Fibrosis in Rats Involves the TGF-β1/Smad Signaling Pathway 