Protective Effect of Triptolide against Glomerular Mesangial Cell Proliferation and Glomerular Fibrosis in Rats Involves the TGF-β1/Smad Signaling Pathway
Table 2
Changes in the biochemical indicators of the groups.
Changes in the biochemical indicators of group
Time (week)
24 h urine protein (mg/24 h)
Urine nitrogen (mol/L)
Creatinine (μmol/L)
Control group
1
1.8 ± 0.24
5.38 ± 0.35
33.68 ± 3.24
2
2.0 ± 0.41
5.32 ± 0.21
32.45 ± 2.65
3
2.3 ± 0.38
5.49 ± 0.28
31.88 ± 2.56
4
1.9 ± 0.54
5.56 ± 0.48
35.27 ± 3.08
Model group
1
8.3 ± 0.61
8.38 ± 0.35
43.67 ± 3.05
2
19.3 ± 3.18
11.32 ± 1.21
52.46 ± 3.65
3
56.3 ± 10.36
13.47 ± 2.08
71.78 ± 4.56
4
124.3 ± 13.42
15.58 ± 3.42
85.19 ± 6.08
Triptolide treatment group
1
5.3 ± 0.52
6.39 ± 0.95
39.68 ± 3.12
2
10.3 ± 2.78
8.32 ± 1.21
42.45 ± 3.61
3
21.3 ± 5.25
10.47 ± 1.48
58.76 ± 4.56
4
48.3 ± 11.32
11.58 ± 1.42
69.21 ± 4.28
= 18–20. Note: when compared to the control group, ; when compared to the model group, ; when comparing the values at different time points in the same group, .
