Unmatched groups ( ,020) Propensity-matched groups ( ,758) Goreisan users ( ,889) Goreisan nonusers ( ,131) Standardized difference Goreisan users ( ,879) Goreisan nonusers ( ,879) Standardized difference Type of hospital, (%) Nonacademic 2,997 (77.1) 27,644 (86.0) 19.6 2,997 (77.3) 3,016 (77.8) 1.0 Academic 892 (22.9) 4,487 (14.0) −19.6 882 (22.7) 863 (22.2) −1.0 Hospital volume (per year), (%) ≤22 1,133 (29.1) 9,836 (30.6) 2.6 1,131 (29.2) 1,098 (28.3) −1.5 23–36 1,283 (33.0) 10,848 (33.8) 1.3 1,275 (32.9) 1,340 (34.5) 2.9 ≥37 1,473 (37.9) 11,447 (35.6) −3.8 1,473 (38.0) 1,441 (37.1) −1.4 Fiscal year, (%) 2010 568 (14.6) 7,748 (24.1) 19.2 568 (14.6) 564 (14.5) −0.2 2011 1,278 (32.9) 12,066 (37.6) 8.0 1,278 (32.9) 1,305 (33.6) 1.2 2012 2,043 (52.5) 12,317 (38.3) −23.6 2,033 (52.4) 2,010 (51.8) −1.0 Age (years), mean (SD) 76.5 (10.7) 76.4 (11.1) −1.4 76.2 (10.7) 76.2 (10.7) 0.0 Sex, (%) Male 2,644 (68.0) 21,577 (67.2) −1.5 2,636 (68.0) 2,618 (67.5) −0.8 Female 1,245 (32.0) 10,554 (32.8) 1.5 1,243 (32.0) 1,261 (32.5) 0.8 Body mass index (kg/m2 ), (%) <18.5 487 (12.5) 4,164 (13.0) 1.1 486 (12.5) 452 (11.7) −2.2 18.5–22.9 1,712 (44.0) 14,065 (43.8) −0.4 1,709 (44.1) 1,746 (45.0) 1.6 23.0–24.9 681 (17.5) 5,356 (16.7) −1.8 681 (17.6) 723 (18.6) 2.3 25.0–29.9 556 (14.3) 4,079 (12.7) −3.9 550 (14.2) 536 (13.8) −0.9 ≥30.0 57 (1.5) 459 (1.4) −0.3 57 (1.5) 46 (1.2) −2.1 Missing 396 (10.2) 4,090 (12.7) 6.4 396 (10.2) 376 (9.7) −1.4 Barthel Index at admission, (%) 0 794 (20.4) 7,676 (23.9) 6.8 794 (20.5) 809 (20.9) 0.8 5–45 671 (17.3) 5,679 (17.7) 0.9 670 (17.3) 609 (15.7) −3.5 50–95 808 (20.8) 6,016 (18.7) −4.2 804 (20.7) 746 (19.2) −3.1 100 894 (23.0) 6,740 (21.0) −4.0 889 (22.9) 991 (25.5) 5.0 Missing 722 (18.6) 6,020 (18.7) 0.4 722 (18.6) 724 (18.7) 0.1 Japan Coma Scale at admission, (%) 0 (alert) 1,809 (46.5) 14,112 (43.9) −4.3 1,799 (46.4) 1,898 (48.9) 4.2 1 digit (drowsy) 1,844 (47.4) 15,124 (47.1) −0.6 1,844 (47.5) 1,747 (45.0) −4.1 2 digits (somnolence) 190 (4.9) 1,965 (6.1) 4.3 190 (4.9) 185 (4.8) −0.5 3 digits (coma) 46 (1.2) 930 (2.9) 9.3 46 (1.2) 49 (1.3) 0.6 Comorbidities, (%) Malignancy 137 (3.5) 1,359 (4.2) 2.9 137 (3.5) 125 (3.2) −1.4 Ischemic heart disease 184 (4.7) 1,562 (4.9) 0.5 184 (4.7) 163 (4.2) −2.2 Chronic heart failure 113 (2.9) 1,057 (3.3) 1.8 113 (2.9) 96 (2.5) −2.2 Chronic renal failure 53 (1.4) 836 (2.6) 6.9 53 (1.4) 47 (1.2) −1.1 Liver cirrhosis 22 (0.6) 163 (0.5) −0.7 22 (0.6) 24 (0.6) 0.5 Pneumonia 27 (0.7) 289 (0.9) 1.8 27 (0.7) 20 (0.5) −1.9 Urinary tract infection 9 (0.2) 104 (0.3) 1.4 9 (0.2) 12 (0.3) 1.2 Sepsis 2 (0.1) 35 (0.1) 1.6 2 (0.1) 3 (0.1) 0.8 Antithrombotic agent use, (%) 317 (8.2) 2,639 (8.2) 0.2 314 (8.1) 278 (7.2) −2.9 Mannitol infusion, (%) 104 (2.7) 1,033 (3.2) 2.6 104 (2.7) 84 (2.2) −2.8 Steroid infusion, (%) 15 (0.4) 243 (0.8) 3.8 15 (0.4) 15 (0.4) 0.0