The Protective Effects of Curcumin on Obesity-Related Glomerulopathy Are Associated with Inhibition of Wnt/β-Catenin Signaling Activation in Podocytes

Figure 1

Cultured conditionally immortalized mouse podocytes in undifferentiated and differentiated statuses. (a) and (b) Morphology of cultured podocytes in undifferentiated status (left) and differentiated status (enlarged cell bodies with short and long projections, right) (phase microscopy ×200). (c) and (d) Diffuse cytoplasmic expression of nephrin in undifferentiated status (left); cell surface and cytoplasmic expression of nephrin in differentiated status (right) (immunofluorescence microscopy ×1000). (e) and (f) No expression of synaptopodin in undifferentiated status (left); filamentous and cell surface expression of synaptopodin in differentiated status (right) (immunofluorescence microscopy ×1000).