The Protective Effects of Curcumin on Obesity-Related Glomerulopathy Are Associated with Inhibition of Wnt/β-Catenin Signaling Activation in Podocytes

Figure 4

Effects of curcumin on renal damage of ORG mice. (a) Average level of nocturnal 12 h urine protein was significantly increased in mice of model group compared with control group and was significantly reduced in curcumin group compared with model group at the 12th week. (b) Average level of creatinine clearance rate was significantly increased in mice of model group compared with control group and was reduced in curcumin group compared with model, but the difference had not reached statistical significance at the 12th week. (c) Histology of kidney tissue from mice of control (A), model (B), and curcumin (C) groups (PAS staining ×400). The average glomerular diameter was significantly longer in the mice of model group than that in control group, while it was significantly shorter in curcumin group than that in model group at the 12th week. Values are represented as mean ± SD (). versus control group, versus control group, and versus model group.