The Protective Effects of Curcumin on Obesity-Related Glomerulopathy Are Associated with Inhibition of Wnt/<i>β</i>-Catenin Signaling Activation in Podocytes

<div>Effects of curcumin on Wnt/<i>β</i>-catenin signaling in the kidney tissue of ORG mice. (a) Mice sacrificed at the end of 12th week. Total RNA was extracted from kidney cortex, and then the relative mRNA expression levels of Wnt1, Wnt2b, Wnt6, and <i>β</i>-catenin were measured by relative quantitative real-time RT-PCR. (b) Kidney cortex was lysed and total lysates were analyzed by Western blot assay with anti-phosphorylated <i>β</i>-catenin antibody and total <i>β</i>-catenin antibody, respectively. The relative phosphorylated <i>β</i>-catenin level was expressed as the phosphorylated <i>β</i>-catenin/total <i>β</i>-catenin ratio. 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id="g117-91"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="587" vert-adv-y="587"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,30.228,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,36.731,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z" id="g113-47"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="228" vert-adv-y="228"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,39.82,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" 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Evidence-Based Complementary and Alternative Medicine

fig7

Figure 7

Figure 7: The Protective Effects of Curcumin on Obesity-Related Glomerulopathy Are Associated with Inhibition of Wnt/<i>β</i>-Catenin Signaling Activation in Podocytes 

Figure 7 | The Protective Effects of Curcumin on Obesity-Related Glomerulopathy Are Associated with Inhibition of Wnt/β-Catenin Signaling Activation in Podocytes 