Involvement of Cholinergic and Opioid System in γ-Terpinene-Mediated Antinociception

Table 1

Antinociceptive effect of the -terpinene in the formalin-induced nociceptive response in mice.

Treatment	Dosage (mg/kg)	Licking time (s)
		0–5 min	Inhibition (%)	15–30 min	Inhibition (%)
Vehicle	—	76.35 ± 10.21	—	70.68 ± 8.18	—
-TPN	6.25	50.48 ± 2.58	33.89	84.79 ± 12.78	−19.96
	12.5	5.96 ± 3.46	92.20	24.13 ± 5.60	65.87
	25	13.74 ± 4.08	82.01	21.18 ± 6.72	70.04
Morphine	5	18.19 ± 3.10	76.18	17.32 ± 5.46	75.50

Mice were treated with -terpinene (-TPN) 60 min (p.o.) before formalin test. Data represent the mean ± SEM of 6–9 mice. Statistical analysis was determined by one-way ANOVA followed by Tukey’s test. ; compared with vehicle.