Author Number and range of age Intervention (herbal medicine and acupoints) and duration Outcomes Adverse events Jadad score Experimental Control Experimental Control Cai 2008 [17 ] 40/2–12 40/2–12 San-Fu-Tie, for one year BCG polysaccharide and nucleic acid injection, twice a week, for three months Symptom rating scale, IL-4, IFN-γ No 2 Mou et al. 2009 [25 ] 91/18–65 55/18–65 San-Fu-Tie, for three consecutive years Oral preparation of traditional Chinese medicine, three months in one year, for three consecutive years Efficacy evaluation, symptom rating scale Not mentioned 2 Cai et al. 2010 [26 ] 60/3–14 60/3–14 San-Fu-Tie, for one year PBO, three times a year, for one year Symptom rating scale, safety assessment No 4 Li and Yuan 2010 [27 ] 30/3–8.2 30/3.2–8.5 San-Fu-Tie, for one year BCG Polysaccharide and nucleic acid injection, once every other day, for one month Efficacy evaluation, One patient had mild skin allergies 4 Zhang 2010 [28 ] 30/18–70 30/18–70 San-Fu-Tie, for three consecutive years Ketotifen, July to September each year, for three consecutive years Efficacy evaluation Not mentioned 2 Tao 2012 [29 ] 60/3–14 60/3–14 San-Fu-Tie, for one year PBO, three times a year, for one year Symptom rating scale No 4 Cui 2012 [20 ] 28/2–14 28/2–14 San-Fu-Tie, for one year Pulmicort, for one year Symptom rating scale, IgA, IgE, IgG, IgM Two patients had local swelling and blisters 2 Li 2012 [30 ] 60/3–14 60/3–14 San-Fu-Tie, for one year PBO, three times a year, for one year Symptom rating scale, safety assessment No 4 Zhu and Chen 2012 [31 ] 36/18–65 36/19–63 San-Fu-Tie, for one year Salbutamol, withdrawal when symptomatic relief occurs Efficacy evaluation Not mentioned 1 You et al. 2012 [32 ] 50/3–80 30/5–81 San-Fu-Tie, for three consecutive years Yupingfeng granules, thirty days during dog days every year, for three consecutive years Efficacy evaluation Not mentioned 2 Chen et al. 2013 [33 ] 56/3–14 30/2.8–14 San-Fu-Tie, for one year Yupingfeng granules, for thirty days during dog days, for one year Efficacy evaluation, IgA, IgE, IgG, IgM Not mentioned 2 Z. P. Zhang 34 ] 60/18–65 60/18–65 San-Fu-Tie, for three consecutive years Acupuncture therapy, thirty days during dog days every year, for three consecutive years Efficacy evaluation Not mentioned 2 Hu 2014 [35 ] 50/5–12 50/5–12 San-Fu-Tie, for one year Salmeterol xinafoate and fluticasone propionate powder for inhalation, for one year Attack frequency, FEV Not mentioned 2 Shi and Zhao 2014 [36 ] 46/3–14 46/2.8–14 San-Fu-Tie, for one year PBO, three times a year, for one year Efficacy evaluation, FEV1 , PEF, FVC, FEV1 /FVC, EOS Not mentioned 5 Chen 2014 [37 ] 70/4–12 70/4–12 San-Fu-Tie, for one year BCG polysaccharide and nucleic acid injection, twice a week, for three months Symptom rating scale, IL-4, IFN-γ Not mentioned 2
Bai Jie Zi, Semen Sinapis Albae ; Xi Xin, Herba Asari ; Gan Sui, Radix Kansui ; Yan Hu Suo, Rhizoma Corydalis ; Sheng Jiang, Rhizome Zingiberis Recens ; Ban Xia, Rhizoma Pinelliae ; Ma Huang, Herba Ephedrae ; Tan Xiang, Lignum Santali Albi ; Rou Gui, Cortex Cinnamomi ; Huang Qi, Radix Astragali ; Dang Shen, Radix Codonopsis ; Shan Yao, Rhizoma Dioscoreae ; Gan Cao, Radix Glycyrrhizae ; Bing Pian, Borneolum Syntheticum ; Jiang Can, Bombyx Batryticatus ; Feng Mi, Mel ; Wu Zhu Yu, Fructus Evodiae ; Su Zi, Fructus Perillae ; She Xiang, Moschus ; Fang Feng, Radix Saposhnikoviae .γ , interferon-γ ; PBO, placebo; FEV1 , Forced Expiratory Volume in One Second; FVC, Forced Vital Capacity; PEFR, Peak Expiratory Flow Rate; PEF, Peak Expiratory Flow; EOS, eosinophils; WBC, white blood cell; NEUT, neutrophil; LYM, lymphocyte; MONO, monocyte; RBC, red blood cell; HGB, hemoglobin; PLT, blood platelet. 