Research Article
Relationship of Genetic Polymorphisms of the Chemokine, CCL5, and Its Receptor, CCR5, with Coronary Artery Disease in Taiwan
Table 2
Odds ratio (OR) and 95% confidence interval (CI) of CAD patients associated with genotyping frequencies of CCL5-403 and CCR5-59029.
| | Variable | Non-CAD () (%) | CAD () (%) | OR (95% CI) | value |
| | CCL5-403 | | | | | | CC | 85 (52.8%) | 148 (46.0%) | 1.00 | | | CT | 70 (43.5%) | 142 (44.1%) | 1.165 (0.788–1.723) |
0.444 | | TT | 6 (3.7%) | 32 (9.9%) | 3.063 (1.231–7.624) | 0.012 | | CC | 85 (52.8%) | 148 (46.0%) | 1.00 | | | CT or TT | 76 (47.2%) | 174 (54.0%) | 1.315 (0.900–1.921) | 0.157 | | C | 240 (74.5%) | 438 (68.0%) | 1.00 | | | T | 82 (25.5%) | 206 (32.0%) | 1.377 (1.019–1.859) | | | CCR5-59029 | | | | | | GG | 67 (41.6%) | 132 (41.0%) | 1.00 | | | GA | 71 (44.1%) | 146 (45.3%) | 1.044 (0.694–1.570) | 0.837 | | AA | 23 (14.3%) | 44 (13.7%) | 0.971 (0.542–1.741) | 0.921 | | GG | 67 (41.6%) | 132 (41.0%) | 1.00 | | | GA or AA | 94 (58.4%) | 190 (59.0%) | 1.026 (0.699–1.506) | 0.896 | | G | 205 (63.7%) | 410 (63.7%) | 1.00 | | | A | 117 (36.3%) | 134 (36.3%) | 1.000 (0.757–1.321) | 1.000 |
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The odds ratio (OR) with their 95% confidence intervals were estimated by logistic regression.
Significance value < 0.05.
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