Research Article
Relationship of Genetic Polymorphisms of the Chemokine, CCL5, and Its Receptor, CCR5, with Coronary Artery Disease in Taiwan
Table 5
Genotyping frequencies and association of demographics features between two alleles of CCR5-59029 for CAD group1.
| | | CCR5-59029 | CCR5-59029 | OR (95% CI) | value | | GG () | GA + AA () |
| | Male | 96 (72.7%) | 144 (75.8%) | 1.174 (0.707–1.949) | 0.535 | | AF positive (%) | 13 (9.8%) | 17 (8.9%) | 0.900 (0.421–1.921) | 0.784 | | CAD risk ≥3 (%) | 80 (60.6%) | 110 (57.9%) | 0.894 (0.568–1.405) | 0.627 | | Age >65 year (%) | 74 (56.1%) | 100 (52.6%) | 0.871 (0.557–1.361) | 0.544 | | Family history (%) | 26 (19.7%) | 33 (17.4%) | 0.857 (0.485–1.515) | 0.595 | | Hypertension (%) | 95 (72.0%) | 147 (77.4%) | 1.331 (0.800–2.216) | 0.270 | | Diabetes mellitus (%) | 65 (49.2%) | 74 (38.9%) | 0.658 (0.420–1.030) | 0.067 | | Active smoker (%) | 54 (40.9%) | 92 (48.4%) | 1.356 (0.866–2.124) | 0.183 | | Cholesterol >200 (%) | 57 (43.5%) | 72 (38.1%) | 0.799 (0.508–1.257) | 0.331 | | ASA use in the past 7 days (%) | 53 (42.7%) | 64 (35.2%) | 0.727 (0.455–1.160) | 0.181 | | Recent (<24 h) sever angina (%) | 86 (65.2%) | 141 (74.6%) | 1.571 (0.967–2.553) | 0.067 | | Cardiac markers elevation (%) | 68 (51.5%) | 126 (66.3%) | 1.853 (1.176–2.921) | 0.008 | | Stroke | 16 (12.6%) | 18 (9.8%) | 0.757 (0.370–1.547) | 0.444 | | CHF | 30 (23.1%) | 37 (20.0%) | 0.833 (0.484–1.436) | 0.511 |
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1Data were presented as number (percentage) with chi-square test/Fisher exact test.
Significance value < 0.05.
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