Evaluation of the Inhibitory Effects of Bavachinin and Bavachin on Human Monoamine Oxidases A and B

Figure 1

Bavachinin (BNN) and bavachin (BVN) inhibitory efficacy on recombinant human monoamine oxidases (hMAOs) compared to Psoralea corylifolia ethanolic extract (PCSEE) and standard MAO-B inhibitor selegiline (DEP) at 8.5 μg/mL. BNN structure (4′-hydroxy-7-methoxy-6-(3-methyl-2-butenyl) flavanone, 7-O-methylbavachin, mw = 338.4) (i) is a BVN analog with the methyl group at C7-OMe position substituting the hydrogen (ii). BNN and BVN differently affected hMAO-B (a) and hMAO-A (b). Data points were presented as the mean ± SEM, for at least . The significance of difference between each control versus treatments for each data set was determined using one-way ANOVA followed by Dunnett’s multiple comparisons test. ; .

(a)

(b)