Evaluation of the Inhibitory Effects of Bavachinin and Bavachin on Human Monoamine Oxidases A and B

Figure 5

Bavachinin (BNN) effects on human monoamine oxidases A and B (hMAO-A and hMAO-B) kinetics. Illustrating the initial velocity () with substrate concentrations ([]) with or without BNN as Lineweaver-Burk plots of hMAO-A (a) and hMAO-B (b). Michaelis-Menten kinetics parameters were presented as folds of change by BNN compared to standard deprenyl (DEP). Parameters are maximum velocity (), Michaelis Constant (), and relative in hMAO-A ((c) and (e) with table) and hMAO-B ((d) and (f) with table), respectively. Data points were presented as the mean ± SEM, , from the average of four separate experiments for BNN and one experiment for DEP. The significance of the difference between the controls versus inhibitors was determined using one-way ANOVA followed by Dunnett’s multiple comparison test. ; ; .

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