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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 854307, 10 pages
Review Article

Review on the Applications and Molecular Mechanisms of Xihuang Pill in Tumor Treatment

1Department of Oncology, Guang’anmen Hospital, China Academy of Chinese Medicine Sciences, No. 5 Beixiange, Xicheng District, Beijing 100053, China
2Beijing University of Chinese Medicine, No. 11 North Third Ring Road East, Chaoyang District, Beijing 100029, China
3Beijing Tongren Hospital, Capital Medical University, No. 2, Chongwenmennei Street, Dongcheng District, Beijing 100730, China
4Institute of Medical Information, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 3 Yabao Road, Chaoyang District, Beijing 100020, China

Received 29 January 2015; Revised 16 May 2015; Accepted 21 May 2015

Academic Editor: Olumayokun A. Olajide

Copyright © 2015 Qiujun Guo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Xihuang pill (XH) is a complementary and alternative medicine that has been used in traditional Chinese medicine (TCM) for the treatment of tumors since the 18th century. XH has clinical effects on non-Hodgkin lymphoma, breast cancer, gastric cancer, liver cancer, and bone metastasis. XH can also inhibit the growth of tumor cells and cancer stem cells, prevent tumor invasion and angiogenesis, and regulate the tumor microenvironment. XH is composed of Ru Xiang (olibanum), Mo Yao (Commiphora myrrha), She Xiang (Moschus), and Niu Huang (Calculus bovis). Some of the compounds found in these ingredients exert multiple antitumor effects and may synergize with the other ingredients. We aimed to summarize the clinical applications and molecular mechanisms of XH and its chemical composition. This review will provide potential new strategies and alternative perspectives for tumor treatments and basic research into complementary and alternative medicine.