| | Authors, year | Guidelines for management | Experimental treatment | Control treatment | Timing of outcome measure | Follow-up | Main outcome |
| | Sun et al., 2007 [24] | SSC 2004 | Conventional therapy plus Shenfu injection (120 mL/day) | Conventional therapy (fluid resuscitation, dopamine) | 6 hours | Not reported | HR, MAP | | Sun et al., 2008 [31] | SSC 2004 | Conventional therapy plus Shenfu injection (120 mL/day) | Conventional therapy (fluid resuscitation, dopamine) | 14 days | Not reported | Mortality | | Zhang et al., 2011 [27] | SSC 2004 | Conventional therapy plus Shenfu injection (120 mL/day) | Conventional therapy (fluid resuscitation, dopamine, correct acidosis, anti-infection) | 6 hours, 14 days | Not reported | HR, MAP, mortality | | Li et al., 2013 [29] | SSC 2008 | Conventional therapy plus Shenfu injection (100 mL/day) | Conventional therapy (fluid resuscitation, dopamine, correct acidosis, anti-infection) | 6 hours, 12 hours, 24 hours | Not reported | Lactate | | Lin et al., 2012 [28] | Not reported | Conventional therapy plus Shenfu injection (100 mL/day) | Conventional therapy (fluid resuscitation, dopamine, correct acidosis, anti-infection) | 24 hours | Not reported | HR | | Xu and Xu, 2012 [25] | Not reported | Conventional therapy plus Shenfu injection (50 mL + 15 mL/hour) | Conventional therapy (fluid resuscitation, dopamine, correct acidosis, anti-infection) | 1 hour, 2 hours, 3 hours, 4 hours, 5 hours, 6 hours | Not reported | Lactate, MAP, HR | | Xu et al., 2013 [26] | SSC 2004 | Conventional therapy plus Shenfu injection (100 mL/day) | Conventional therapy (fluid resuscitation, dopamine, correct acidosis, anti-infection) | 6 hours | Not reported | Mortality, MAP, HR, lactate | | He et al., 2013 [19] | SSC 2008 | Conventional therapy plus Shenfu injection (100 mL/day) | Conventional therapy (anti-infection treatment, fluid resuscitation, glucose monitoring, cortical hormone) | 15 days | 6 months | Lactate, mortality | | Lin et al., 2013 [30] | Not reported | Conventional therapy plus Shenfu injection (120 mL/day) | Conventional therapy (treatment of primary condition, fluid resuscitation, anti-infection, nutrition support) | 6 hours, 24 hours, 72 hours | Not reported | Lactate, mortality | | Lv et al., 2013 [23] | Not reported | Conventional therapy plus Shenfu injection (1 mL/Kg) | Conventional therapy (fluid resuscitation, dopamine, correct acidosis, anti-infection) | 1 hour, 8 hours, 12 hours, 24 hours | Not reported | HR, MAP, lactate, mortality | | Dong and Shen, 2014 [18] | SSC 2008 | Conventional therapy plus Shenfu injection (100 mL/day) | Conventional therapy (fluid resuscitation, dopamine, correct acidosis, anti-infection) | 6 hours, 24 hours, 28 days | Not reported | HR, MAP, lactate, mortality | | Liu et al., 2014 [22] | Not reported | Conventional therapy plus Shenfu injection (150 mL/day) | Conventional therapy (fluid resuscitation, norepinephrine) | 1 hour, 2 hours, 3 hours, 4 hours, 5 hours, 6 hours | Not reported | MAP, HR, lactate |
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