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Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 864597, 6 pages
Research Article

Qing Re Liang Xue Decoction Alleviates Hypercoagulability in Kawasaki Disease

1Department of Pediatrics, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China
2Research Department Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100045, China

Received 29 December 2014; Revised 7 March 2015; Accepted 14 March 2015

Academic Editor: Zhang Tan

Copyright © 2015 Jiao-yang Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. Kawasaki disease (KD) is a multisystemic autoimmune vasculitis. Intravenous immunoglobulin (IVIG) is the first-line treatment for KD. It is unclear whether traditional Chinese medicine (TCM) has an effect on KD. We aimed to observe the clinical efficacy of TCM on acute KD via serum interleukin-33 (IL-33) and tumor necrosis factor alpha (TNF-α) measurements. Methods. Thirty-one KD patients were treated with Qing Re Liang Xue decoction and Western medicine (integrative medicine treatment group), while 28 KD patients were treated with Western medicine only (Western medicine treatment group). Thirty patients were included in a febrile group and 28 healthy children were included in the control group. Clinical characteristics and laboratory findings were gathered and compared. Serum IL-33 and TNF-α levels were measured by multiplex Luminex assay. Results. The platelet count in the integrative medicine treatment group was significantly lower than that in the Western medicine treatment group. The integrative medicine group had a shorter fever duration and lower IL-33 and TNF-α levels than those in the Western medicine group, but there were no significant differences between the two KD groups after treatment. Conclusion. Qing Re Liang Xue decoction improved the hypercoagulable state of KD patients. Potential myocardial protective effects require further research.