Chronic Treatment with a Water-Soluble Extract from the Culture Medium of Ganoderma lucidum Mycelia Prevents Apoptosis and Necroptosis in Hypoxia/Ischemia-Induced Injury of Type 2 Diabetic Mouse Brain

Figure 5

Effects of chronic pretreatment with MAK (1 g/kg) on expression of apoptosis factors gene expression after H/I. Expression levels of Bcl-2 (a) and Bax (b) mRNA after H/I at 24 h of reoxygenation after H/I in the penumbral cortex from the mice in each group, determined by real-time RT-PCR analysis. (c) The Bcl-2/Bax ratio was calculated. in each group. , 0.001 compared with the sham-operated control group, , 0.01 compared with the H/I-treated control group.