Research Article
Fallopia japonica, a Natural Modulator, Can Overcome Multidrug Resistance in Cancer Cells
Table 2
Effect of TCM drugs (100
g/mL) on activities of ABC transporters, GST, and CYP3A4.
|
Plant (family) | Metabolic activity | MDR inhibition % | GST activity (mol/min/mL) | CYP3A4 inhibition % |
| Areca catechu (Arecaceae) | 1.27 ± 0.13 | 23.46 ± 3.34 | 56.94 ± 4.35 | Cassia tora (Fabaceae) | 8.84 ± 0.97 | 31.81 ± 3.54 | 16.38 ± 3.08 | Chrysanthemum indicum (Asteraceae) | 9.83 ± 0.89 | 22.86 ± 1.54 | 46.18 ± 4.99 | Cymbopogon distans (Poaceae) | 0.28 ± 0.03 | 9.54 ± 1.02 | 2.71 ± 1.53 | Cynanchum paniculatum (Apocynaceae) | 19.29 ± 4.32 | 15.70 ± 1.72 | 22.62 ± 3.62 | Desmodium styracifolium (Fabaceae) | 171.24 ± 18.54 | 10.93 ± 1.32 | 10.22 ± 3.12 | Kadsura longipedunculata (Schisandraceae) | 2.99 ± 0.35 | 10.14 ± 1.39 | 48.30 ± 4.70 | Mentha haplocalyx (Lamiaceae) | 8.96 ± 1.00 | 12.92 ± 1.81 | 1.19 ± 0.37 | Ophioglossum vulgatum (Ophioglossaceae) | 1.21 ± 0.15 | 13.91 ± 1.96 | 24.91 ± 0.54 | Paris polyphylla (Melanthiaceae) | 15.41 ± 2.01 | 18.88 ± 2.11 | 2.92 ± 1.18 | Patrinia scabiosaefolia (Valerianaceae) | 6.32 ± 0.82 | 27.43 ± 1.32 | 0.61 ± 0.04 | Fallopia japonica (Polygonaceae) | 179.94 ± 18.34 | 14.11 ± 1.23 | 39.81 ± 4.68 | Sanguisorba officinalis (Rosaceae) | 35.82 ± 4.65 | 19.88 ± 3.43 | 59.96 ± 3.52 | Saposhnikovia divaricata (Apiaceae) | 134.38 ± 15.9 | 7.35 ± 0.67 | 8.21 ± 3.14 | Taxillus chinensis (Loranthaceae) | 43.60 ± 5.76 | 9.94 ± 1.9 | 47.41 ± 1.07 | Viola yezoensis (Violaceae) | 65.77 ± 6.89 | 15.31 ± 2.85 | 24.97 ± 2.75 |
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MDR inhibition calculated as % compared to verapamil as positive control (100%). Data are means ± S.D. from three independent experiments.
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