Evaluation of Sedative and Hypnotic Activity of Ethanolic Extract of Scoparia dulcis Linn.
Table 1
Effect of EESD on hole cross test.
Treatment
Dose (mg/kg)
Number of holes crossed (% of inhibition)
Pretreatment
30 min
60 min
90 min
120 min
Control
0.1 mL/mouse
19 ± 1.58
17.60 ± 0.75
15.6 ± 0.93
13.4 ± 0.51
12.4 ± 0.51
Diazepam
1
21.2 ± 1.63
5.2 ± 1.16* (70.45)
3.2 ± 0.37* (79.49)
2.0 ± 0.45* (85.07)
2.2 ± 0.74* (82.26)
EESD
50
18.6 ± 1.69
12.6 ± 1.54* (28.41)
10.2 ± 1.20* (34.62)
7.2 ± 1.16* (46.27)
4.2 ± 0.97* (66.13)
EESD
100
20.4 ± 1.08
8.80 ± 0.49* (50.00)
7.8 ± 1.02* (50.00)
3.6 ± 0.81* (73.13)
3.2 ± 0.86* (74.19)
EESD
200
21 ± 0.84
6.0 ± 0.84* (65.91)
2.0 ± 0.71* (87.18)
1.6 ± 0.4* (88.06)
1.2 ± 0.37* (90.32)
Values are presented as the Mean ± SEM (). EESD = ethanolic extract of Scoparia dulcis; compared with the control group (two-way ANOVA followed by Bonferroni’s test).