Evaluation of Sedative and Hypnotic Activity of Ethanolic Extract of Scoparia dulcis Linn.

Table 2

Effect of EESD on open field test.

Treatment	Dose (mg/kg)	Number of squares crossed (% of inhibition)
		Pretreatment	30 min	60 min	90 min	120 min
Control	0.1 mL/mouse	102.8 ± 2.99	93.2 ± 3.31	83 ± 3.67	67.8 ± 1.93	56.4 ± 2.79
Diazepam	1	97.4 ± 6.08	47.4 ± 1.66^* (49.14)	29.2 ± 2.46^* (64.82)	13.6 ± 2.09^* (79.94)	8.8 ± 0.86^* (84.40)
EESD	50	95.2 ± 5.83	59.4 ± 1.66^* (36.27)	43.4 ± 3.50^* (47.71)	27.6 ± 5.85^* (59.29)	19.6 ± 2.32^* (65.25)
EESD	100	99.4 ± 6.40	46.6 ± 9.32^* (50)	31.8 ± 4.87^* (61.69)	15.8 ± 2.91^* (76.70)	9.8 ± 2.76^* (82.62)
EESD	200	98.4 ± 5.34	39.6 ± 1.50^* (57.51)	20.6 ± 2.25^* (75.18)	7.6 ± 0.93^* (88.79)	3.20 ± 0.86^* (94.33)

Values are presented as the Mean ± SEM (). EESD = ethanolic extract of Scoparia dulcis; compared with the control group (two-way ANOVA followed by Bonferroni’s test).