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| Natural products | Experimental models | Possible mechanisms | Reference |
|
| 2,3,5,4′-Tetrahydroxystilbene-2-O--D-glucoside of Polygonum multiflorum | Human blood (in vitro);
agonist: collagen | Inhibition of FcRIIa, Akt (Ser473), and GSK3 (Ser9) phosphorylation | [105] |
|
| 95% ethanol extract of Spatholobus suberectus | Human blood (in vitro);
agonist: collagen | Blockage of fibrinogen binding to the GP IIb/IIIa, suppression of TXA2 formation | [106] |
|
| A new tripeptide (AAP) of Agkistrodon acutus Venom | Rabbit blood (in vitro);
agonist: ADP, PAF-acether, collagen and THR | Inhibition of fibrinogen binding to GP IIb/IIIa | [107] |
|
| Glaucocalyxin A of Rabdosia japonica (Burm. f.) var. glaucocalyx (Maxim.) Hara | Human blood (in vitro);
agonist: collagen | Inhibition of tyrosine phosphorylation of Syk, LAT, phospholipase Cγ2, and P-selectin secretion | [108] |
|
| Salvianolic acid B of Salvia miltiorrhiza | Rat blood (in vitro and ex vivo);
agonist: collagen | Exerting binding affinity to , decreasing of intracellular Ca2+, and impacting on cytoskeleton-related proteins level | [109] |
|
| Indole-3-carbinol of cruciferous vegetables | Human blood (in vitro);
agonist: collagen | Inhibition of fibrinogen binding to GP IIb/IIIa and decreasing the levels of TXB2, prostaglandin E2 | [110] |
|
| II-3,I-5,II-5,II-7,I-4′,II-4′-Hexahydroxy-(I-3,II-8)-flavonylflavanonol and acacetin of Garcinia nervosa var. pubescens King | Rabbit blood (in vitro);
agonist: PAF | Possessing strong PAF antagonistic activity | [111] |
|
| Essential oils of five Goniothalamus species | Human blood (in vitro);
agonist: ADP, AA, and collagen | Possessing strong PAF antagonistic activity | [112] |
|
| 15–20% ethanol extract of aged garlic | Human blood (in vitro);
agonist: ADP | Inhibition of fibrinogen binding to GP IIb/IIIa and increasing the level of cAMP | [113] |
|
| Tetramethylpyrazine of Ligusticam wallichii Franch | Human blood (in vitro);
agonist: ADP, collagen, and U46619 | Inhibition of fibrinogen binding to GP IIb/IIIa and the levels of intracellular Ca2+ as well as TXB2 | [114] |
|
| Aqueous extract of Agrimonia pilosa | Human blood (in vitro);
agonist: ADP | Inhibition of fibrinogen binding to GP IIb/IIIa and decreasing the level of P-selectin | [115] |
|
| N-butanol extract of Toona sinensis Seed | Human blood (in vitro);
agonist: THR | Inhibition of fibrinogen binding to GP IIb/IIIa and decreasing the level of intracellular Ca2+ | [116] |
|
| Eryloside F of Erylus formosus | Human blood (in vitro);
agonist: THR, SFLLRN, and U-46619 | Possessing strong THR antagonistic activity | [117] |
|
| Isomaltol and pentagalloyl glucose of Rhus verniciflua Stokes | Human blood (in vitro);
agonist: ADP, AA, and collagen | Decreasing the expression of GPIIb/IIIa | [118] |
|
| Piperlongumine of Piper longum L. | Rabbit blood (in vitro);
agonist: U4619 and THR | Inhibition of U46619-induced phosphatidylinositol hydrolysis as well as the binding of (3H)SQ29548 to TXA2 receptor | [119] |
|
| Hot-water extract of modified Je-Ho-Tang (Mume Fructus, Amomi Tsaoko Fructus, Santali Albi Lignum, and Amomi Fructus) | Human blood (in vitro);
agonist: collagen | Inhibiting adhesion and decreasing the activation of GPIIb/IIIa-like expression and P-selectin monoclonal, Ca2+ mobilization | [120] |
|
| Pomolic acid of Licania pittieri | Human blood (in vitro);
agonist: ADP | Competitive antagonism of ADP-induced platelet aggregation | [121] |
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