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| Natural products | Experimental models | Possible mechanisms | Reference |
|
| Epigallocatechin-3-gallate of green tea leaves | Rat blood (in vitro);
agonist: collagen | Inhibiting the activation of COX-1 and TXAS, with a stronger selectivity in COX-1 inhibition than TXAS inhibition | [133] |
|
| Jujuboside B of seeds of Zizyphus jujuba | Rat blood (in vitro);
agonist: collagen | Inhibition of TXA2 production | [134] |
|
| Alditol and monosaccharide of sorghum vinegar | Human blood (in vitro);
agonist: AA, collagen, ADP, and THR | Inhibition of COX-1 and TXAS and attenuating TXA2 production | [135] |
|
| Diacetylated obovatol of Magnolia obovata leaves | Rabbit blood (in vitro);
agonist: collagen and AA | Inhibition of COX-1 and LOX activities and decreasing in cytosolic Ca2+ mobilization and 5-HT secretion | [136] |
|
| Ethanol extract, eupatilin, and jaceosidin of Artemisia princeps Pampanini | Human blood (in vitro);
agonist: AA | Inhibition the generation of 5-HT and TXA2 | [137] |
|
| Berberine of berberine sulfate injection | Rabbit blood (ex vivo);
agonist: ADP, AA, and collagen | Suppressing of TXA2 | [138] |
|
| Hesperetin of grapefruits and oranges | Rabbit blood (in vitro);
agonist: AA and collagen | Inhibition of PLC-γ2 phosphorylation, COX-1 activity, and decreasing of Ca2+ as well as TXA2 | [139] |
|
| Green tea catechins of Camellia sinensis | Rabbit blood (in vitro);
agonist: AA, collagen, and U-46619 | Inhibition of AA liberation, TXA2 synthesis, PGD2, and ATP formation | [140] |
|
| Hydroxychavicol of betel quid | Rat blood (in vitro);
agonist: AA, collagen, and THR | Inhibition of COX-1/COX-2 enzyme activity and decreasing TXA2 and ROS production as well as Ca2+ mobilization | [141] |
|
| Tetrandrine and fangchinoline of Radix Stephaniae Tetrandrae | Human blood (in vitro);
agonist: PAF, THR and AA | Suppression of TXA2 formation, but without inhibiting the binding of PAF to PAF-receptor | [142] |
|
| Isorhynchophy lline of Uncaria sinensis (Oliv.) Havil. | Rabbit blood (in vitro);
agonist: collagen | Inhibition of TXA2 formation | [143] |
|
| Genistein | Rabbit blood (in vitro);
agonist: PAF | Inhibition of TXA2 formation and increasing PGI2 generation | [144] |
|
| Ethyl acetate extract of Caesalpinia sappan L. | Rat blood (ex vivo);
agonist: ADP | Inhibition of TXA2 formation and increasing PGI2 generation | [145] |
|
| Morroniside of Cornus officinalis Sieb.et Zucc | Rabbit blood (in vitro);
agonist: ADP | Inhibition of COX activation and decreasing TXB2 generation | [146, 147] |
|
| Neolignans of three Lauraceae species (Pleurothyrium cinereum, Ocotea macrophylla, and Nectandra amazonum) | Rabbit blood (in vitro)
agonist: PAF, ADP and AA | Inhibition of COX-2 by Benzofuran neolignans; inhibition of PAF-action, COX-1, 5-LOX by bicyclooctane; inhibition of COX-2, PAF-action by neolignan 9-nor-7,8-dehydro-isolicarin B and cinerin C; inhibition of 5-LOX/COX-2 by Nectamazin C | [148] |
|
| Extracts of Myoga (Zingiber mioga Roscoe) | Human blood (in vitro)
agonist: ADP and AA | Inhibition of 5-LOX by miogatrial, miogadial, sesquiterpene and polygodial | [149] |
|
| Ginsenoside Rk1 of white ginseng | Rat blood (in vitro)
agonist: AA | Decreasing of 12-HETE, 12-LOX, and Ca2+ levels | [150] |
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