Metabolomics Profiling to Investigate the Pharmacologic Mechanisms of Berberine for the Treatment of High-Fat Diet-Induced Nonalcoholic Steatohepatitis

Table 1

Change in serum parameters of rats fed on a standard diet (NC), high-fat diet (M), or HFD with the berberine (Ber) treatment for eight weeks (, ).

Index	NC	M	Ber
ALT (U/L)	19.49 ± 4.68	40.67 ± 9.47^**	20.92 ± 5.56^##
AST (U/L)	199.88 ± 30.74	390.60 ± 59.13^**	281.57 ± 70.86^##
CHO (mmol/L)	1.68 ± 0.19	2.81 ± 0.79^*	2.07 ± 0.22^#
TG (mmol/L)	0.56 ± 0.04	1.65 ± 0.12^*	0.65 ± 0.13^##
LDL-C (mmol/L)	0.16 ± 0.02	0.81 ± 0.42^*	0.54 ± 0.38
Glucose (mmol/L)	3.51 ± 0.67	4.74 ± 2.20^*	3.24 ± 1.17^#
Insulin (mIU/L)	16.67 ± 4.0	17.09 ± 2.40	15.77 ± 3.53
HOMA index	2.6 ± 0.68	3.6 ± 3.02^*	2.3 ± 0.75^#

Note: , compared with NC group; , compared with NC group; and , compared with M group.