Table 2: Anti-inflammatory effects of Lonicerae japonicae flos and Lonicerae flos.

SpeciesPart/compoundDetection methodsReferences

Lonicerae japonicae flosWater extractCarrageenan-induced paw swelling model, dimethylbenzene/formalin-induced inflammatory model, cotton ball granulomatous hyperplasia model, cervicitis model, Escherichia coli infection model, Raw264.7 cell activation model, trypsin-induced mast cell activation model, human keratinocyte three-dimensional culture inflammatory activation model[50, 52, 54, 56, 5961]
Alcohol extract 30%Croton oil-induced inflammatory model[55]
Alcohol extract 57%Egg white-induced paw swelling model, dimethylbenzene-induced inflammatory model[51, 53]
Alcohol extract 70%LPS-induced Raw264.7 cell activation model[62]
Alcohol extract 95%Resection wound model, H1N1-infected human bronchial epithelial cell line A549 model[57, 156]
Alcohol extractOvalbumin-induced asthma model[58]
Supercritical carbon dioxide extractDimethylbenzene-induced inflammatory model[51]



Lonicerae flos
Water extract of Lonicera macranthoides Hand.-Mazz.Formalin pain model, acetic acid-writhing model, xylene-induced inflammation model, carrageenan-induced paw swelling model, yeast thermal model[85]
Water extract of Lonicera macranthoides Hand.-Mazz. flowerAcetic acid-induced capillary permeability increase model, paw swelling model, cotton ball granulomatous hyperplasia model[102]
Supercritical carbon dioxide extract of Lonicera macranthoides Hand.-Mazz.Acetic acid-induced abdominal capillary permeability increase model, carrageenan-induced paw swelling model, pleuritis model, cotton ball granulomatous hyperplasia model[65, 66]
Water extract 50% and alcohol extract 95% of Lonicera hypoglauca Miq.Dimethylbenzene-induced inflammation model, carrageenan-induced paw swelling model, cotton ball granulomatous hyperplasia model[64]